Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b)
1_MAAPP 6_ APAAK 11_ GSPQP 16_ EPHAP 21_ EPGPG 26_ SAKRG 31_ REDSR 36_ AGRLS 41_ FCTKV 46_ CYGIG 51_ GVPNQ 56_ IASSA 61_ TAFYL 66_ QLFLL 71_ DIAQI 76_ PAAQV 81_ SLVLF 86_ GGKVS 91_ GAAAD 96_ PVAGF 101_ FINRS 106_ QRTGS 111_ GRLMP 116_ WVLGC 121_ TPFIA 126_ LAYFF 131_ LWFLP 136_ PFTSL 141_ RGLWY 146_ TTFYC 151_ LFQAL 156_ ATFFQ 161_ VPYTA 166_ LTMLL 171_ TPCPR 176_ ERDSA 181_ TAYRM 186_ TVEMA 191_ GTLMG 196_ ATVHG 201_ LIVSG 206_ AHRPH 211_ RCEAT 216_ ATPGP 221_ VTVSP 226_ NAAHL 231_ YCIAA 236_ AVVVV 241_ TYPVC 246_ ISLLC 251_ LGVKE 256_ RPDPS 261_ APASG 266_ PGLSF 271_ LAGLS 276_ LTTRH 281_ PPYLK 286_ LVISF 291_ LFISA 296_ AVQVE 301_ QSYLV 306_ LFCTH 311_ ASQLH 316_ DHVQG 321_ LVLTV 326_ LVSAV 331_ LSTPL 336_ WEWVL 341_ QRFGK 346_ KTSAF 351_ GIFAM 356_ VPFAI 361_ LLAAV 366_ PTAPV 371_ AYVVA 376_ FVSGV 381_ SIAVS 386_ LLLPW 391_ SMLPD 396_ VVDDF 401_ QLQHR 406_ HGPGL 411_ ETIFY 416_ SSYVF 421_ FTKLS 426_ GACAL 431_ GISTL 436_ SLEFS 441_ GYKAG 446_ VCKQA 451_ EEVVV 456_ TLKVL 461_ IGAVP 466_ TCMIL 471_ AGLCI 476_ LMVGS 481_ TPKTP 486_ SRDAS 491_ SRLSL 496_RRRTS
1: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable)