Gene name: TLCD2

Uniprot entry:

A6NGC4

Protein names:

TLC domain-containing protein 2

Protein sequence:

1_MAPTG 6_ LLVAG 11_ ASFLA 16_ FRGLH 21_ WGLRR 26_ LPTPE 31_ SAARD 36_ RWQWW 41_ NLCVS 46_ LAHSL 51_ LSGTG 56_ ALLGL 61_ SLYPQ 66_ MAADP 71_ IHGHP 76_ RWALV 81_ LVAVS 86_ VGYFL 91_ ADGAD 96_ LLWNQ 101_ TLGKT 106_ WDLLC 111_ HHLVV 116_ VSCLS 121_ TAVLS 126_ GHYVG 131_ FSMVS 136_ LLLEL 141_ NSACL 146_ HLRKL 151_ LLLSR 156_ QAPSL 161_ AFSVT 166_ SWASL 171_ ATLAL 176_ FRLVP 181_ LGWMS 186_ LWLFR 191_ QHHQV 196_ PLALV 201_ TLGGI 206_ GLVTV 211_ GIMSI 216_ ILGIR 221_ ILVND 226_ VLQSR 231_ PHPPS 236_ PGHEK 241_ TRGTR 246_ TRRDN 251_ GPVTS 256_NSSTL

Protein annotations

Protein functions:

1: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349)