Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19)
1_MVDDA 6_ GAAES 11_ QRGKQ 16_ TPAHS 21_ LEQLR 26_ RLPLP 31_ PPQIR 36_ IRPWW 41_ FPVQE 46_ LRDPL 51_ VFYLE 56_ AWLAD 61_ ELFGP 66_ DRAII 71_ PEMEW 76_ TSQAL 81_ LTVDI 86_ VDSGN 91_ LVEIT 96_ VFGRP 101_ RVQNR 106_ VKSML 111_ LCLAW 116_ FHREH 121_ RARAE 126_ KMKHL 131_ EKNLK 136_ AHASD 141_PHSPQ
1: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis