rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase)
1_MKSAA 6_ SSRGG 11_ GGGGR 16_ GGGGW 21_ GSWGG 26_ GRGGG 31_ GGAGK 36_ GGGGD 41_ GGGQG 46_ GKGGF 51_ GARAR 56_ GFGGG 61_ GRGRG 66_ RGGGD 71_ GKDRG 76_ GGGQR 81_ RGGVA 86_ KSKSR 91_ RRKGA 96_ MVVSV 101_ EPHRH 106_ EGVFI 111_ YRGAE 116_ DALVT 121_ LNMVP 126_ GQSVY 131_ GERRV 136_ TVTEG 141_ GVKQE 146_ YRTWN 151_ PFRSK 156_ LAAAI 161_ LGGVD 166_ QIHIK 171_ PKSKV 176_ LYLGA 181_ ASGTT 186_ VSHVS 191_ DIIGP 196_ DGLVY 201_ AVEFS 206_ HRAGR 211_ DLVNV 216_ AKKRT 221_ NIIPV 226_ LEDAR 231_ HPLKY 236_ RMLIG 241_ MVDVI 246_ FADVA 251_ QPDQS 256_ RIVAL 261_ NAHTF 266_ LRNGG 271_ HFLIS 276_ IKANC 281_ IDSTA 286_ SAEAV 291_ FASEV 296_ RKLQQ 301_ ENLKP 306_ QEQLT 311_ LEPYE 316_ RDHAV 321_ VVGVY 326_RPLPK
1: S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes 2'-hydroxyl ribose methylation in RNAs (PubMed:39570315). Functions as part of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes, where guide snoRNAs ensure methylation specificity through base pairing with RNA substrates (PubMed:39570315). Exhibits broad substrate specificity, methylating multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) depending on the guide snoRNA incorporated in the complex (PubMed:39570315). Specifically expressed in brain, it regulates the expression of GAP43 by stabilizing its mRNA through methylation and thereby plays an indirect role in neuronal differentiation (By similarity)