Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)
1_METLC 6_ PAPRL 11_ AVPAS 16_ PRGSP 21_ CSPTP 26_ RKPCR 31_ GTQEF 36_ SPLCL 41_ RALAF 46_ CALAK 51_ PRASS 56_ LGPGP 61_ GELAA 66_ RSPVL 71_ RGPQA 76_ PLRPG 81_ GWAPD 86_ GLKHL 91_ WAPTG 96_ RPGVP 101_ NTAAG 106_ EDADV 111_ AACPR 116_ RGEEE 121_ EGGGG 126_ FPHFG 131_ VRSCA 136_ PPGRC 141_ PAPPH 146_ PREST 151_ TSFAS 156_ APPRP 161_ APGLE 166_ PQRGP 171_ AASPP 176_ QEPSS 181_ RPPSP 186_ PAGLS 191_ TEPAG 196_ PGTAP 201_ RPFLP 206_ GQPAE 211_ VDGNP 216_ PPAAP 221_ EAPAA 226_ SPSTA 231_ SPAPA 236_ APGDL 241_ RQEHF 246_ DRLIR 251_ RSKLW 256_ CYAKG 261_ FALDT 266_ PSLRR 271_ GPERP 276_ PAKGP 281_ ARGAA 286_ KKRRL 291_ PAPPP 296_ RTAQP 301_ RRPAP 306_ TLPTT 311_ STFSL 316_ LNCFP 321_ CPPAL 326_ VVGED 331_ GDLKP 336_ ASSLR 341_ LQGDS 346_ KPPPA 351_ HPLWR 356_ WQMGG 361_ PAVPE 366_ PPGLK 371_FWGIN
1: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation