Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)
1_MAAAD 6_ GGGPG 11_ GASVG 16_ TEEDG 21_ GGVGH 26_ RTVYL 31_ FDRRE 36_ KESEL 41_ GDRPL 46_ QVGER 51_ SDYAG 56_ FRACV 61_ CQTLG 66_ ISPEE 71_ KFVIT 76_ TTSRK 81_ EITCD 86_ NFDET 91_ VKDGV 96_ TLYLL 101_ QSVNQ 106_ LLLTA 111_ TKERI 116_ DFLPH 121_ YDTLV 126_ KSGMY 131_ EYYAS 136_ EGQNP 141_ LPFAL 146_ AELID 151_ NSLSA 156_ TSRNI 161_ GVRRI 166_ QIKLL 171_ FDETQ 176_ GKPAV 181_ AVIDN 186_ GRGMT 191_ SKQLN 196_ NWAVY 201_ RLSKF 206_ TRQGD 211_ FESDH 216_ SGYVR 221_ PVPVP 226_ RSLNS 231_ DISYF 236_ GVGGK 241_ QAVFF 246_ VGQSA 251_ RMISK 256_ PADSQ 261_ DVHEL 266_ VLSKE 271_ DFEKK 276_ EKNKE 281_ AIYSG 286_ YIRNR 291_ KPSDS 296_ VHITN 301_ DDERF 306_ LHHLI 311_ IEEKE 316_ KDSFT 321_ AVVIT 326_ GVQPE 331_ HIQYL 336_ KNYFH 341_ LWTRQ 346_ LAHIY 351_ HYYIH 356_ GPKGN 361_ EIRTS 366_ KEVEP 371_ FNNID 376_ IEISM 381_ FEKGK 386_ VPKIV 391_ NLREI 396_ QDDMQ 401_ TLYVN 406_ TAADS 411_ FEFKA 416_ HVEGD 421_ GVVEG 426_ IIRYH 431_ PFLYD 436_ RETYP 441_ DDPCF 446_ PSKLK 451_ DEDDE 456_ DDCFI 461_ LEKAA 466_ RGKRP 471_ IFECF 476_ WNGRL 481_ IPYTS 486_ VEDFD 491_ WCTPP 496_ KKRGL 501_ APIEC 506_ YNRIS 511_ GALFT 516_ NDKFQ 521_ VSTNK 526_ LTFMD 531_ LELKL 536_ KDKNT 541_ LFTRI 546_ LNGQE 551_ QRMKI 556_ DREFA 561_ LWLKD 566_ CHEKY 571_ DKQIK 576_ FTLFK 581_ GVITR 586_ PDLPS 591_ KKQGP 596_ WATYA 601_ AIEWD 606_ GKIYK 611_ AGQLV 616_ KTIKT 621_ LPLFY 626_ GSIVR 631_ FFLYG 636_ DHDGE 641_ VYATG 646_ GEVQI 651_ AMEPQ 656_ ALYDE 661_ VRTVP 666_ IAKLD 671_ RTVAE 676_ KAVKK 681_ YVEDE 686_ MARLP 691_ DRLSV 696_ TWPEG 701_ DELLP 706_ NEVRP 711_ AGTPI 716_ GALRI 721_ EILNK 726_ KGEAM 731_ QKLPG 736_ TSHGG 741_ SKKLL 746_ VELKV 751_ ILHSS 756_ SGNKE 761_ IISHI 766_ SQHGG 771_ KWPYW 776_ FKKME 781_ NIQKL 786_ GNYTL 791_ KLQVV 796_ LNESN 801_ ADTYA 806_ GRPLP 811_ SKAIK 816_ FSVKE 821_ GKPEK 826_ FSFGL 831_ LDLPF 836_ RVGVP 841_ FNIPL 846_ EFQDE 851_ FGHTS 856_ QLVTD 861_ IQPVL 866_ EASGL 871_ SLHYE 876_ EITKG 881_ PNCVI 886_ RGVTA 891_ KGPVN 896_ SCQGK 901_ NYNLK 906_ VTLPG 911_ LKEDS 916_ QILKI 921_ RLLPG 926_ HPRRL 931_ KVKPD 936_ SEILV 941_ IENGT 946_ AFPFQ 951_ VEVLD 956_ ESDNI 961_ TAQPK 966_ LIVHC 971_ KFSGA 976_ PNLPV 981_ YVVDC 986_ SSSGT 991_ SILTG 996_ SAIQV 1001_ QNIKK 1006_ DQTLK 1011_ ARIEI 1016_ PSCKD 1021_ VAPVE 1026_ KTIKL 1031_ LPSSH 1036_ VARLQ 1041_ IFSVE 1046_ GQKAI 1051_ QIKHQ 1056_ DEVNW 1061_ IAGDI 1066_ MHNLI 1071_ FQMYD 1076_ EGERE 1081_ INITS 1086_ ALAEK 1091_ IKVNW 1096_ TPEIN 1101_ KEHLL 1106_ QGLLP 1111_ DVQVP 1116_ TSVKD 1121_ MRYCQ 1126_ VSFQD 1131_ DHVSL 1136_ ESAFT 1141_ VRPLP 1146_ DEPKH 1151_ LKCEM 1156_ KGGKT 1161_ VQMGQ 1166_ ELQGE 1171_ VVIII 1176_ TDQYG 1181_ NQIQA 1186_ FSPSS 1191_ LSSLS 1196_ IAGVG 1201_ LDSSN 1206_ LKTTF 1211_ QENTQ 1216_ SISVR 1221_ GIKFI 1226_ PGPPG 1231_ NKDLC 1236_ FTWRE 1241_ FSDFI 1246_ RVQLI 1251_ SGPPA 1256_ KLLLI 1261_ DWPEL 1266_ KESIP 1271_ VINGR 1276_ DLQNP 1281_ IIVQL 1286_ CDQWD 1291_ NPAPV 1296_ QHVKI 1301_ SLTKA 1306_ SNLKL 1311_ MPSNQ 1316_ QHKTD 1321_ EKGRA 1326_ NLGVF 1331_ SVFAP 1336_ RGEHT 1341_ LQVKA 1346_ IYNKS 1351_ IIEGP 1356_ IIKLM 1361_ ILPDP 1366_ EKPVR 1371_ LNVKY 1376_ DKDAS 1381_ FLAGG 1386_ LFTDF 1391_ MISVI 1396_ SEDDS 1401_ IIKNI 1406_ NPARI 1411_ SMKMW 1416_ KLSTS 1421_ GNRPP 1426_ ANAET 1431_ FSCNK 1436_ IKDND 1441_ KEDGC 1446_ FYFRD 1451_ KVIPN 1456_ KVGTY 1461_ CIQFG 1466_ FMMDK 1471_ TNILN 1476_ SEQVI 1481_ VEVLP 1486_ NQPVK 1491_ LVPKI 1496_ KPPTP 1501_ AVSNV 1506_ RSVAS 1511_ RTLVR 1516_ DLHLS 1521_ ITDDY 1526_ DNHTG 1531_ IDLVG 1536_ TIIAT 1541_ IKGSN 1546_ EEDTD 1551_ TPLFI 1556_ GKVRT 1561_ LEFPF 1566_ VNGSA 1571_ EIMSL 1576_ VLAES 1581_ SPGRD 1586_ STEYF 1591_ IVFEP 1596_ RLPLL 1601_ SRTLE 1606_ PYILP 1611_ FMFYN 1616_ DVKKQ 1621_ QQMAA 1626_ LTKEK 1631_ DQLSQ 1636_ SIVMY 1641_ KSLFE 1646_ ASQQL 1651_ LNEMK 1656_ CQVEE 1661_ ARLKE 1666_ AQLRN 1671_ ELKIH 1676_ NIDIP 1681_ TTQQV 1686_ PHIEA 1691_ LLKRK 1696_ LSEQE 1701_ ELKKK 1706_ PRRSC 1711_ TLPNY 1716_ TKGSG 1721_ DVLGK 1726_ IAHLA 1731_ QIEDD 1736_ RAAMV 1741_ ISWHL 1746_ ASDMD 1751_ CVVTL 1756_ TTDAA 1761_ RRIYD 1766_ ETQGR 1771_ QQVLP 1776_ LDSIY 1781_ KKTLP 1786_ DWKRS 1791_ LPHFR 1796_ NGKLY 1801_ FKPIG 1806_ DPVFA 1811_ RDLLT 1816_ FPDNV 1821_ EHCET 1826_ VFGML 1831_ LGDTI 1836_ ILDNL 1841_ DAANH 1846_ YRKEV 1851_ VKITH 1856_ CPTLL 1861_ TRDGD 1866_ RIRSN 1871_ GKFGG 1876_ LQNKA 1881_ PPMDK 1886_ LRGMV 1891_ FGAPV 1896_ PKQCL 1901_ ILGEQ 1906_ IDLLQ 1911_ QYRSA 1916_ VCKLD 1921_ SVNKD 1926_ LNSQL 1931_ EYLRT 1936_ PDMRK 1941_ KKQEL 1946_ DEHEK 1951_ NLKLI 1956_ EEKLG 1961_ MTPIR 1966_ KCNDS 1971_ LRHSP 1976_ KVETT 1981_ DCPVP 1986_ PKRMR 1991_ REATR 1996_QNRII
1: Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876)