Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)
1_MELHI 6_ LEHRL 11_ QVASV 16_ AKESI 21_ PLFTY 26_ GLIKL 31_ AFLSS 36_ KTRCK 41_ FFSLT 46_ ETPED 51_ YTIIV 56_ DEEGF 61_ LELPS 66_ SEHLS 71_ VADAT 76_ WLALN 81_ VVSGG 86_ GSFSS 91_ SQPIG 96_ VTKIA 101_ KSVIA 106_ PLADQ 111_ NISVF 116_ MLSTY 121_ QTDFI 126_ LVRER 131_ DLPFV 136_ THTLS 141_ SEFTI 146_ LRVVN 151_ GETVA 156_ AENLG 161_ ITNGF 166_ VKPKL 171_ VQRPV 176_ IHPLS 181_ SPSNR 186_ FCVTS 191_ LDPDT 196_ LPAVA 201_ TLLMD 206_ VMFYS 211_ NGVKD 216_ PMATG 221_ DDCGH 226_ IRFFS 231_ FSLIE 236_ GYISL 241_ VMDVQ 246_ TQQRF 251_ PSNLL 256_ FTSAS 261_ GELWK 266_ MVRIG 271_ GQPLG 276_ FDECG 281_ IVAQI 286_ SEPLA 291_ AADIP 296_ AYYIS 301_ TFKFD 306_ HALVP 311_ EENIN 316_ GVISA 321_LKVSQ
1: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway