Protein chibby homolog 3
1_MWASR 6_ DHLPE 11_ PDLGD 16_ AAPPG 21_ SPSSF 26_ WTSGL 31_ PRQER 36_ STSRQ 41_ RSRGS 46_ PSSTC 51_ VPYKV 56_ HALAT 61_ FECSA 66_ TSHAS 71_ RLWQT 76_ LQQFW 81_ ADHIS 86_ RPFSP 91_ RRPPL 96_ RRMPS 101_ LSTFY 106_ LLDHN 111_ TRQAE 116_ LGLAY 121_ GAPCM 126_ RLSNQ 131_ AFVFR 136_ GGRWT 141_ TESQL 146_ ARTRS 151_ PLLSR 156_ TAWGW 161_ KAQVQ 166_ RSKSQ 171_ VLLEE 176_ NNYLK 181_ LQQEL 186_ LIDML 191_ TETMA 196_ RMHLL 201_ EKQRN 206_ PEVIP 211_ TAAAR 216_ AGQRK 221_ MRKRA 226_ GASAG 231_ VLMIQ 236_PCALD
1: Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). CBY3 interacts with CIBAR1 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity)