Wilms tumor protein 1-interacting protein (WT1-interacting protein)
1_MQRSR 6_ AGADE 11_ AALLL 16_ AGLAL 21_ RELEP 26_ GCGSP 31_ GRGRR 36_ GPRPG 41_ PGDEA 46_ APALG 51_ RRGKG 56_ SGGPE 61_ AGADG 66_ LSRGE 71_ RGPRR 76_ AAVPE 81_ LSAQP 86_ AGSPR 91_ ASLAG 96_ SDGGG 101_ GGGSA 106_ RSSGI 111_ SLGYD 116_ QRHGS 121_ PRSGR 126_ SDPRP 131_ GPGPP 136_ SVGSA 141_ RSSVS 146_ SLGSR 151_ GSAGA 156_ YADFL 161_ PPGAC 166_ PAPAR 171_ SPEPA 176_ GPAPF 181_ PLPAL 186_ PLPPG 191_ REGGP 196_ SAAER 201_ RLEAL 206_ TRELE 211_ RALEA 216_ RTARD 221_ YFGIC 226_ IKCGL 231_ GIYGA 236_ QQACQ 241_ AMGSL 246_ YHTDC 251_ FTCDS 256_ CGRRL 261_ RGKAF 266_ YNVGE 271_ KVYCQ 276_ EDFLY 281_ SGFQQ 286_ TADKC 291_ SVCGH 296_ LIMEM 301_ ILQAL 306_ GKSYH 311_ PGCFR 316_ CSVCN 321_ ECLDG 326_ VPFTV 331_ DVENN 336_ IYCVR 341_ DYHTV 346_ FAPKC 351_ ASCAR 356_ PILPA 361_ QGCET 366_ TIRVV 371_ SMDRD 376_ YHVAC 381_ YHCED 386_ CGLQL 391_ SGEEG 396_ RRCYP 401_ LAGHL 406_ LCRRC 411_ HLRRL 416_ QPGPL 421_PSPTV
1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity)