Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)
1_MMLKS 6_ ITESF 11_ ATAIH 16_ GLKVG 21_ HLTDR 26_ VIQRS 31_ KRMIL 36_ DTLGA 41_ GFLGT 46_ TTEVF 51_ HIASQ 56_ YSKIY 61_ SSNIS 66_ STVWG 71_ QPDIR 76_ LPPTY 81_ AAFVN 86_ GVAIH 91_ SMDFD 96_ DTWHP 101_ ATHPS 106_ GAVLP 111_ VLTAL 116_ AEALP 121_ RSPKF 126_ SGLDL 131_ LLAFN 136_ VGIEV 141_ QGRLL 146_ HFAKE 151_ ANDMP 156_ KRFHP 161_ PSVVG 166_ TLGSA 171_ AAASK 176_ FLGLS 181_ STKCR 186_ EALAI 191_ AVSHA 196_ GAPMA 201_ NAATQ 206_ TKPLH 211_ IGNAA 216_ KHGIE 221_ AAFLA 226_ MLGLQ 231_ GNKQV 236_ LDLEA 241_ GFGAF 246_ YANYS 251_ PKVLP 256_ SIASY 261_ SWLLD 266_ QQDVA 271_ FKRFP 276_ AHLST 281_ HWVAD 286_ AAASV 291_ RKHLV 296_ AERAL 301_ LPTDY 306_ IKRIV 311_ LRIPN 316_ VQYVN 321_ RPFPV 326_ SEHEA 331_ RHSFQ 336_ YVACA 341_ MLLDG 346_ GITVP 351_ SFHEC 356_ QINRP 361_ QVREL 366_ LSKVE 371_ LEYPP 376_ DNLPS 381_ FNILY 386_ CEISV 391_ TLKDG 396_ ATFTD 401_ RSDTF 406_ YGHWR 411_ KPLSQ 416_ EDLEE 421_ KFRAN 426_ ASKML 431_ SWDTV 436_ ESLIK 441_ IVKNL 446_ EDLED 451_ CSVLT 456_ TLLKG 461_ PSPPE 466_ VASNS 471_ PACNN 476_SITNL
1: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:31548418, PubMed:35662396). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity)