Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like)
1_MPALL 6_ LLVLL 11_ ASSAG 16_ QARAR 21_ PSNAT 26_ SAEPA 31_ GPLPA 36_ LLAHL 41_ RRLTG 46_ ALTGG 51_ GGAAS 56_ PGANG 61_ TRTGP 66_ AGGAG 71_ AAARA 76_ PPPAE 81_ LCHGY 86_ YDVMG 91_ QYDAT 96_ FNCST 101_ GSYRF 106_ CCGTC 111_ HYRFC 116_ CEHRH 121_ MRLAQ 126_ ASCSN 131_ YDTPR 136_ WATTP 141_ PPLAG 146_ GAGGA 151_ GGAGG 156_ GPGPG 161_ QAGWL 166_ EGGRT 171_ GGAGG 176_ RGGEG 181_ PGGST 186_ AYVVC 191_ GVISF 196_ ALAVG 201_ VGAKV 206_ AFSKA 211_ SRAPR 216_ AHRDI 221_ NVPRA 226_ LVDIL 231_ RHQAG 236_ PGTRP 241_ DRARS 246_ SSLTP 251_ GIGGP 256_ DSMPP 261_ RTPKN 266_ LYNTV 271_ KTPNL 276_ DWRAL 281_ PPPSP 286_ SLHYS 291_ TLSCS 296_ RSFHN 301_ LSHLP 306_ PSYEA 311_ AVKSE 316_ LNRYS 321_ SLKRL 326_ AEKDL 331_ DEAYL 336_ KRRPL 341_ ELPRG 346_ TLPLH 351_ ALRRP 356_ GTGGG 361_ YRMEA 366_ WGGPE 371_ ELGLA 376_ PAPNP 381_ RRVMS 386_ QEHLL 391_ GDGGR 396_ SRYEF 401_ TLPRA 406_ RLVSQ 411_ EHLLL 416_ SSPEA 421_ LRQSR 426_ EHLLS 431_ PPRSP 436_ ALPPD 441_ PTARA 446_ SLAAS 451_ HSNLL 456_ LGPGG 461_ PPTPL 466_ RGLPP 471_ PSSLH 476_ AHHHH 481_ ALHGS 486_ PQPAW 491_ MSDAG 496_ GGGGT 501_ LARRP 506_ PFQRQ 511_ GTLEQ 516_ LQFIP 521_ GHHLP 526_ QHLRT 531_ASKNE
1: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses