Fidgetin-like protein 2
1_MHWTP 6_ EHAQP 11_ LNQWP 16_ EQHLD 21_ VSSTT 26_ PSPAH 31_ KLELP 36_ PGGRQ 41_ RCHYA 46_ WAHDD 51_ ISALT 56_ ASNLL 61_ KRYAE 66_ KYSGV 71_ LDSPY 76_ ERPAL 81_ GGYSD 86_ ASFLN 91_ GAKGD 96_ PEPWP 101_ GPEPP 106_ YPLAS 111_ LHEGL 116_ PGTKS 121_ GGGGG 126_ SGALG 131_ GSPVL 136_ AGNLP 141_ EPLYA 146_ GNACG 151_ GPSAA 156_ PEYAA 161_ GYGGG 166_ YLAPG 171_ YCAQT 176_ GAALP 181_ PPPPA 186_ ALLQP 191_ PPPPG 196_ YGPSA 201_ PLYNY 206_ PAGGY 211_ AAQPG 216_ YGALP 221_ PPPGP 226_ PPAPY 231_ LTPGL 236_ PAPTP 241_ LPAPA 246_ PPTAY 251_ GFPTA 256_ APGAE 261_ SGLSL 266_ KRKAA 271_ DEGPE 276_ GRYRK 281_ YAYEP 286_ AKAPV 291_ ADGAS 296_ YPAAD 301_ NGECR 306_ GNGFR 311_ AKPPG 316_ AAEEA 321_ SGKYG 326_ GGVPL 331_ KVLGS 336_ PVYGP 341_ QLEPF 346_ EKFPE 351_ RAPAP 356_ RGGFA 361_ VPSGE 366_ TPKGV 371_ DPGAL 376_ ELVTS 381_ KMVDC 386_ GPPVQ 391_ WADVA 396_ GQGAL 401_ KAALE 406_ EELVW 411_ PLLRP 416_ PAYPG 421_ SLRPP 426_ RTVLL 431_ FGPRG 436_ AGKAL 441_ LGRCL 446_ ATQLG 451_ ATLLR 456_ LRGAT 461_ LAAPG 466_ AAEGA 471_ RLLQA 476_ AFAAA 481_ RCRPP 486_ SVLLI 491_ SELEA 496_ LLPAR 501_ DDGAA 506_ AGGAL 511_ QVPLL 516_ ACLDG 521_ GCGAG 526_ ADGVL 531_ VVGTT 536_ SRPAA 541_ LDEAT 546_ RRRFS 551_ LRFYV 556_ ALPDS 561_ PARGQ 566_ ILQRA 571_ LAQQG 576_ CALSE 581_ RELAA 586_ LVQGT 591_ QGFSG 596_ GELGQ 601_ LCQQA 606_ AAGAG 611_ LPGLQ 616_ RPLSY 621_ KDLEA 626_ ALAKV 631_ GPRAS 636_ AKELD 641_ SFVEW 646_DKMYG
1: Microtubule-severing enzyme that negatively regulates cell migration and wound healing (PubMed:25756798, PubMed:36523161). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (PubMed:25756798, PubMed:36523161). Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility (PubMed:36523161). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (By similarity). Contributes to proper cell branching during endothelial and neuronal development (By similarity)