Olfactory receptor 2AT4 (Olfactory receptor OR11-265)
1_MDATA 6_ CNESV 11_ DGSPV 16_ FYLLG 21_ IPSLP 26_ ETFFL 31_ PVFFI 36_ FLLFY 41_ LLILM 46_ GNALI 51_ LVAVV 56_ AEPSL 61_ HKPMY 66_ FFLIN 71_ LSTLD 76_ ILFTT 81_ TTVPK 86_ MLSLF 91_ LLGDR 96_ FLSFS 101_ SCLLQ 106_ MYLFQ 111_ SFTCS 116_ EAFIL 121_ VVMAY 126_ DRYVA 131_ ICHPL 136_ HYPVL 141_ MNPQT 146_ NATLA 151_ ASAWL 156_ TALLL 161_ PIPAV 166_ VRTSQ 171_ MAYNS 176_ IAYIY 181_ HCFCD 186_ HLAVV 191_ QASCS 196_ DTTPQ 201_ TLMGF 206_ CIAMV 211_ VSFLP 216_ LLLVL 221_ LSYVH 226_ ILASV 231_ LRISS 236_ LEGRA 241_ KAFST 246_ CSSHL 251_ LVVGT 256_ YYSSI 261_ AIAYV 266_ AYRAD 271_ LPLDF 276_ HIMGN 281_ VVYAI 286_ LTPIL 291_ NPLIY 296_ TLRNR 301_ DVKAA 306_ ITKIM 311_SQDPG
1: Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264)