Dehydrogenase/reductase SDR family member 7C (EC 1.1.1.105) (Sarcoplasmic reticulum protein of 35 kDa) (Protein SRP-35) (Short-chain dehydrogenase/reductase family 32C member 2) (Protein SDR32C2)
1_MGVMA 6_ MLMLP 11_ LLLLG 16_ ISGLL 21_ FIYQE 26_ VSRLW 31_ SKSAV 36_ QNKVV 41_ VITDA 46_ ISGLG 51_ KECAR 56_ VFHTG 61_ GARLV 66_ LCGKN 71_ WERLE 76_ NLYDA 81_ LISVA 86_ DPSKQ 91_ TFTPK 96_ LVLLD 101_ LSDIS 106_ CVPDV 111_ AKEVL 116_ DCYGC 121_ VDILI 126_ NNASV 131_ KVKGP 136_ AHKIS 141_ LELDK 146_ KIMDA 151_ NYFGP 156_ ITLTK 161_ ALLPN 166_ MISRR 171_ TGQIV 176_ LVNNI 181_ QGKFG 186_ IPFRT 191_ TYAAS 196_ KHAAL 201_ GFFDC 206_ LRAEV 211_ EEYDV 216_ VISTV 221_ SPTFI 226_ RSYHV 231_ YPEQG 236_ NWEAS 241_ IWKFF 246_ FRKLT 251_ YGVHP 256_ VEVAE 261_ EVMRT 266_ VRRKK 271_ QEVFM 276_ ANPIP 281_ KAAVY 286_ VRTFF 291_ PEFFF 296_ AVVAC 301_ GVKEK 306_LNVPE
1: NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid