Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)
1_MCKDY 6_ VYDKD 11_ IEQIA 16_ KEEQG 21_ EALKL 26_ QASTS 31_ TEVSH 36_ QQCSV 41_ PGLGE 46_ KFPTW 51_ ETTKP 56_ ELELL 61_ GHNPR 66_ RRRIT 71_ SSFTI 76_ GLRGL 81_ INLGN 86_ TCFMN 91_ CIVQA 96_ LTHTP 101_ ILRDF 106_ FLSDR 111_ HRCEM 116_ PSPEL 121_ CLVCE 126_ MSSLF 131_ RELYS 136_ GNPSP 141_ HVPYK 146_ LLHLV 151_ WIHAR 156_ HLAGY 161_ RQQDA 166_ HEFLI 171_ AALDV 176_ LHRHC 181_ KGDDV 186_ GKAAN 191_ NPNHC 196_ NCIID 201_ QIFTG 206_ GLQSD 211_ VTCQA 216_ CHGVS 221_ TTIDP 226_ CWDIS 231_ LDLPG 236_ SCTSF 241_ WPMSP 246_ GRESS 251_ VNGES 256_ HIPGI 261_ TTLTD 266_ CLRRF 271_ TRPEH 276_ LGSSA 281_ KIKCG 286_ SCQSY 291_ QESTK 296_ QLTMN 301_ KLPVV 306_ ACFHF 311_ KRFEH 316_ SAKQR 321_ RKITT 326_ YISFP 331_ LELDM 336_ TPFMA 341_ SSKES 346_ RMNGQ 351_ LQLPT 356_ NSGNN 361_ ENKYS 366_ LFAVV 371_ NHQGT 376_ LESGH 381_ YTSFI 386_ RHHKD 391_ QWFKC 396_ DDAVI 401_ TKASI 406_ KDVLD 411_ SEGYL 416_ LFYHK 421_ QVLEH 426_ ESEKV 431_KEMNT
1: Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008, PubMed:32027733). Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (PubMed:32027733). Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (PubMed:32027733). Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008). Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity). By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity)