YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3) (ApoA-I-binding protein 2)
1_MSSAA 6_ GPDPS 11_ EAPEE 16_ RHFLR 21_ ALELQ 26_ PPLAD 31_ MGRAE 36_ LSSNA 41_ TTSLV 46_ QRRKQ 51_ AWGRQ 56_ SWLEQ 61_ IWNAG 66_ PVCQS 71_ TAEAA 76_ ALERE 81_ LLEDY 86_ RFGRQ 91_ QLVEL 96_ CGHAS 101_ AVAVT 106_ KAFPL 111_ PALSR 116_ KQRTV 121_ LVVCG 126_ PEQNG 131_ AVGLV 136_ CARHL 141_ RVFEY 146_ EPTIF 151_ YPTRS 156_ LDLLH 161_ RDLTT 166_ QCEKM 171_ DIPFL 176_ SYLPT 181_ EVQLI 186_ NEAYG 191_ LVVDA 196_ VLGPG 201_ VEPGE 206_ VGGPC 211_ TRALA 216_ TLKLL 221_ SIPLV 226_ SLDIP 231_ SGWDA 236_ ETGSD 241_ SEDGL 246_ RPDVL 251_ VSLAA 256_ PKRCA 261_ GRFSG 266_ RHHFV 271_ AGRFV 276_ PDDVR 281_ RKFAL 286_ RLPGY 291_TGTDC
1: May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (PubMed:17533573)