Zinc finger SWIM domain-containing protein 8
1_MELMF 6_ AEWED 11_ GERFS 16_ FEDSD 21_ RFEED 26_ SLCSF 31_ ISEAE 36_ SLCQN 41_ WRGWR 46_ KQSAG 51_ PNSPT 56_ GGGGG 61_ GGSGG 66_ TRMRD 71_ GLVIP 76_ LVELS 81_ AKQVA 86_ FHIPF 91_ EVVEK 96_ VYPPV 101_ PEQLQ 106_ LRIAF 111_ WSFPE 116_ NEEDI 121_ RLYSC 126_ LANGS 131_ ADEFQ 136_ RGDQL 141_ FRMRA 146_ VKDPL 151_ QIGFH 156_ LSATV 161_ VPPQM 166_ VPPKG 171_ AYNVA 176_ VMFDR 181_ CRVTS 186_ CSCTC 191_ GAGAK 196_ WCTHV 201_ VALCL 206_ FRIHN 211_ ASAVC 216_ LRAPV 221_ SESLS 226_ RLQRD 231_ QLQKF 236_ AQYLI 241_ SELPQ 246_ QILPT 251_ AQRLL 256_ DELLS 261_ SQSTA 266_ INTVC 271_ GAPDP 276_ TAGPS 281_ ASDQS 286_ TWYLD 291_ ESTLT 296_ DNIKK 301_ TLHKF 306_ CGPSP 311_ VVFSD 316_ VNSMY 321_ LSSTE 326_ PPAAA 331_ EWACL 336_ LRPLR 341_ GREPE 346_ GVWNL 351_ LSIVR 356_ EMFKR 361_ RDSNA 366_ APLLE 371_ ILTDQ 376_ CLTYE 381_ QITGW 386_ WYSVR 391_ TSASH 396_ SSASG 401_ HTGRS 406_ NGQSE 411_ VAAHA 416_ CASMC 421_ DEMVT 426_ LWRLA 431_ VLDPA 436_ LSPQR 441_ RRELC 446_ TQLRQ 451_ WQLKV 456_ IENVK 461_ RGQHK 466_ KTLER 471_ LFPGF 476_ RPAVE 481_ ACYFN 486_ WEEAY 491_ PLPGV 496_ TYSGT 501_ DRKLA 506_ LCWAR 511_ ALPSR 516_ PGASR 521_ SGGLE 526_ ESRDR 531_ PRPLP 536_ TEPAV 541_ RPKEP 546_ GTKRK 551_ GLGEG 556_ VPSSQ 561_ RGPRR 566_ LSAEG 571_ GDKAL 576_ HKMGP 581_ GGGKA 586_ KALGG 591_ AGSGS 596_ KGSAG 601_ GGSKR 606_ RLSSE 611_ DSSLE 616_ PDLAE 621_ MSLDD 626_ SSLAL 631_ GAEAS 636_ TFGGF 641_ PESPP 646_ PCPLH 651_ GGSRG 656_ PSTFL 661_ PEPPD 666_ TYEED 671_ GGVYF 676_ SEGPE 681_ PPTAS 686_ VGPPG 691_ LLPGD 696_ VCTQD 701_ DLPST 706_ DESGN 711_ GLPKT 716_ KEAAP 721_ AVGEE 726_ DDDYQ 731_ AYYLN 736_ AQDGA 741_ GGEEE 746_ KAEGG 751_ AGEEH 756_ DLFAG 761_ LKPLE 766_ QESRM 771_ EVLFA 776_ CAEAL 781_ HAHGY 786_ SSEAS 791_ RLTVE 796_ LAQDL 801_ LANPP 806_ DLKVE 811_ PPPAK 816_ GKKNK 821_ VSTSR 826_ QTWVA 831_ TNTLS 836_ KAAFL 841_ LTVLS 846_ ERPEH 851_ HNLAF 856_ RVGMF 861_ ALELQ 866_ RPPAS 871_ TKALE 876_ VKLAY 881_ QESEV 886_ AALLK 891_ KIPLG 896_ PSEMS 901_ TMRCR 906_ AEELR 911_ EGTLC 916_ DYRPV 921_ LPLML 926_ ASFIF 931_ DVLCA 936_ PGSRP 941_ PSRNW 946_ NSETP 951_ GDEEL 956_ GFEAA 961_ VAALG 966_ MKTTV 971_ SEAEH 976_ PLLCE 981_ GTRRE 986_ KGDLA 991_ LALMI 996_ TYKDD 1001_ QAKLK 1006_ KILDK 1011_ LLDRE 1016_ SQTHK 1021_ PQTLS 1026_ SFYSS 1031_ SRPTT 1036_ ASQRS 1041_ PSKHG 1046_ GPSAP 1051_ GALQP 1056_ LTSGS 1061_ AGPAQ 1066_ PGSVA 1071_ GAGPG 1076_ PTEGF 1081_ TEKNV 1086_ PESSP 1091_ HSPCE 1096_ GLPSE 1101_ AALTP 1106_ RPEGK 1111_ VPSRL 1116_ ALGSR 1121_ GGYNG 1126_ RGWGS 1131_ PGRPK 1136_ KKHTG 1141_ MASID 1146_ SSAPE 1151_ TTSDS 1156_ SPTLS 1161_ RRPLR 1166_ GGWAP 1171_ TSWGR 1176_ GQDSD 1181_ SISSS 1186_ SSDSL 1191_ GSSSS 1196_ SGSRR 1201_ ASASG 1206_ GARAK 1211_ TVEVG 1216_ RYKGR 1221_ RPESH 1226_ APHVP 1231_ NQPSE 1236_ AAAHF 1241_ YFELA 1246_ KTVLI 1251_ KAGGN 1256_ SSTSI 1261_ FTHPS 1266_ SSGGH 1271_ QGPHR 1276_ NLHLC 1281_ AFEIG 1286_ LYALG 1291_ LHNFV 1296_ SPNWL 1301_ SRTYS 1306_ SHVSW 1311_ ITGQA 1316_ MEIGS 1321_ AALTI 1326_ LVECW 1331_ DGHLT 1336_ PPEVA 1341_ SLADR 1346_ ASRAR 1351_ DSNMV 1356_ RAAAE 1361_ LALSC 1366_ LPHAH 1371_ ALNPN 1376_ EIQRA 1381_ LVQCK 1386_ EQDNL 1391_ MLEKA 1396_ CMAVE 1401_ EAAKG 1406_ GGVYP 1411_ EVLFE 1416_ VAHQW 1421_ FWLYE 1426_ QTAGG 1431_ SSTAR 1436_ EGATS 1441_ CSASG 1446_ IRAGG 1451_ EAGRG 1456_ MPEGR 1461_ GGPGT 1466_ EPVTV 1471_ AAAAV 1476_ TAAAT 1481_ VVPVI 1486_ SVGSS 1491_ LYPGP 1496_ GLGHG 1501_ HSPGL 1506_ HPYTA 1511_ LQPHL 1516_ PCSPQ 1521_ YLTHP 1526_ AHPAH 1531_ PMPHM 1536_ PRPAV 1541_ FPVPS 1546_ SAYPQ 1551_ GVHPA 1556_ FLGAQ 1561_ YPYSV 1566_ TPPSL 1571_ AATAV 1576_ SFPVP 1581_ SMAPI 1586_ TVHPY 1591_ HTEPG 1596_ LPLPT 1601_ SVACE 1606_ LWGQG 1611_ TVSSV 1616_ HPAST 1621_ FPAIQ 1626_ GASLP 1631_ ALTTQ 1636_ PSPLV 1641_ SGGFP 1646_ PPEEE 1651_ THSQP 1656_ VNPHS 1661_ LHHLH 1666_ AAYRV 1671_ GMLAL 1676_ EMLGR 1681_ RAHND 1686_ HPNNF 1691_ SRSPP 1696_ YTDDV 1701_ KWLLG 1706_ LAAKL 1711_ GVNYV 1716_ HQFCV 1721_ GAAKG 1726_ VLSPF 1731_ VLQEI 1736_ VMETL 1741_ QRLSP 1746_ AHAHN 1751_ HLRAP 1756_ AFHQL 1761_ VQRCQ 1766_ QAYMQ 1771_ YIHHR 1776_ LIHLT 1781_ PADYD 1786_ DFVNA 1791_ IRSAR 1796_ SAFCL 1801_ TPMGM 1806_ MQFND 1811_ ILQNL 1816_ KRSKQ 1821_ TKELW 1826_ QRVSL 1831_EMATF
1: Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity)
2: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation