Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)
1_MASVQ 6_ QGEKQ 11_ LFEKF 16_ WRGTF 21_ KAVAT 26_ PRPES 31_ IIVAS 36_ ITARK 41_ PLPRT 46_ EPQNN 51_ PVVPA 56_ QDGPS 61_ EKLGQ 66_ HLATE 71_ PLGTN 76_ SWERD 81_ KTCRE 86_ LGATR 91_ GHSAS 96_ HDKDL 101_ TPPPS 106_ SRGKK 111_ KKKKS 116_ TRKKR 121_ RRSSS 126_ YSPSP 131_ VKKKK 136_ KKSSK 141_ KHKRR 146_ RSFSK 151_ KRRHS 156_ SSSPK 161_ SKRRD 166_ EKRHK 171_ KQSRS 176_ RPRKS 181_ HRHRH 186_ HRCPS 191_ RSQSS 196_ ESRPS 201_ SCESR 206_ HRGRS 211_ PEEGQ 216_ KSRRR 221_ HSRRC 226_ SKTLC 231_ KDSPE 236_ AQSSR 241_ PPSQP 246_ LQMLG 251_ YLSAR 256_ GVITG 261_ SGSAA 266_ DLFTK 271_ TASPL 276_ TTSRG 281_ RSQEY 286_ DSGND 291_ TSSPP 296_ STQTS 301_ SARSR 306_ GQEKG 311_ SPSGG 316_ LSKSR 321_ ELNSG 326_ NTSDS 331_ GNSFT 336_ TSSPQ 341_ NKGAM 346_ LENLS 351_ PTSRG 356_ RESRG 361_ FQSPC 366_ LECAE 371_ VKKSS 376_ LVPST 381_ ARSSP 386_ MKGCS 391_ RSSSY 396_ ASTRS 401_ SSHSS 406_ RSPNP 411_ RASPR 416_ YTQSR 421_ STSSE 426_ KRSYS 431_ RSPSY 436_ SSKSG 441_ KRSPP 446_ SRSSR 451_ SRRSP 456_ SYSRY 461_ SPSRE 466_ RDPKY 471_ SEKDS 476_ QQRER 481_ ERARR 486_ RRRSY 491_ SPMRK 496_ RRRDS 501_ PSHLE 506_ ARRIT 511_ SARKR 516_ PIPYY 521_ RPSPS 526_ SSGSL 531_ SSTSS 536_ WYSSS 541_ SSRSA 546_ SRSYS 551_ RSRSR 556_ SRSRR 561_ RSRTR 566_ TSSSS 571_ SSRSP 576_ SPGSR 581_ SRSRS 586_ RSRSR 591_ SRSRS 596_ QSRSY 601_ SSADS 606_YSSTR
1: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity)