WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)
1_MTPVR 6_ MQHSL 11_ AGQTY 16_ AVPFI 21_ QPDLR 26_ REEAV 31_ QQMAD 36_ ALQYL 41_ QKVSG 46_ DIFSR 51_ ISQQV 56_ EQSRS 61_ QVQAI 66_ GEKVS 71_ LAQAK 76_ IEKIK 81_ GSKKA 86_ IKVFS 91_ SAKYP 96_ APGRL 101_ QEYGS 106_ IFTGA 111_ QDPGL 116_ QRRPR 121_ HRIQS 126_ KHRPL 131_ DERAL 136_ QEKLK 141_ DFPVC 146_ VSTKP 151_ EPEDD 156_ AEEGL 161_ GGLPS 166_ NISSV 171_ SSLLL 176_ FNTTE 181_ NLYKK 186_ YVFLD 191_ PLAGA 196_ VTKTH 201_ VMLGA 206_ ETEEK 211_ LFDAP 216_ LSISK 221_ REQLE 226_ QQVPE 231_ NYFYV 236_ PDLGQ 241_ VPEIH 246_ VPSYL 251_ PDLPG 256_ IANDL 261_ MYSAD 266_ LGPGI 271_ APSAP 276_ GTIPE 281_ LPTFH 286_ TEVAE 291_ PLKVD 296_ LQDGV 301_ LTPPP 306_ PPPPP 311_ PPAPE 316_ VLASA 321_ PPLPP 326_ STAAP 331_ VGQGA 336_ RQDDS 341_ SSSAS 346_ PSVQG 351_ APREV 356_ VDPSG 361_ GWATL 366_ LESIR 371_ QAGGI 376_ GKAKL 381_ RSMKE 386_ RKLEK 391_ QQQKE 396_ QEQVR 401_ ATSQG 406_ GHLMS 411_ DLFNK 416_ LVMRR 421_ KGISG 426_ KGPGA 431_ GEGPG 436_ GAFVR 441_ VSDSI 446_ PPLPP 451_ PQQPQ 456_AEEDE
1: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity)