Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)
1_MWAQL 6_ LLGML 11_ ALSPA 16_ IAEEL 21_ PNYLV 26_ TLPAR 31_ LNFPS 36_ VQKVC 41_ LDLSP 46_ GYSDV 51_ KFTVT 56_ LETKD 61_ KTQKL 66_ LEYSG 71_ LKKRH 76_ LHCIS 81_ FLVPP 86_ PAGGT 91_ EEVAT 96_ IRVSG 101_ VGNNI 106_ SFEEK 111_ KKVLI 116_ QRQGN 121_ GTFVQ 126_ TDKPL 131_ YTPGQ 136_ QVYFR 141_ IVTMD 146_ SNFVP 151_ VNDKY 156_ SMVEL 161_ QDPNS 166_ NRIAQ 171_ WLEVV 176_ PEQGI 181_ VDLSF 186_ QLAPE 191_ AMLGT 196_ YTVAV 201_ AEGKT 206_ FGTFS 211_ VEEYV 216_ LPKFK 221_ VEVVE 226_ PKELS 231_ TVQES 236_ FLVKI 241_ CCRYT 246_ YGKPM 251_ LGAVQ 256_ VSVCQ 261_ KANTY 266_ WYREV 271_ EREQL 276_ PDKCR 281_ NLSGQ 286_ TDKTG 291_ CFSAP 296_ VDMAT 301_ FDLIG 306_ YAYSH 311_ QINIV 316_ ATVVE 321_ EGTGV 326_ EANAT 331_ QNIYI 336_ SPQMG 341_ SMTFE 346_ DTSNF 351_ YHPNF 356_ PFSGK 361_ IRVRG 366_ HDDSF 371_ LKNHL 376_ VFLVI 381_ YGTNG 386_ TFNQT 391_ LVTDN 396_ NGLAP 401_ FTLET 406_ SGWNG 411_ TDVSL 416_ EGKFQ 421_ MEDLV 426_ YNPEQ 431_ VPRYY 436_ QNAYL 441_ HLRPF 446_ YSTTR 451_ SFLGI 456_ HRLNG 461_ PLKCG 466_ QPQEV 471_ LVDYY 476_ IDPAD 481_ ASPDQ 486_ EISFS 491_ YYLIG 496_ KGSLV 501_ MEGQK 506_ HLNSK 511_ KKGLK 516_ ASFSL 521_ SLTFT 526_ SRLAP 531_ DPSLV 536_ IYAIF 541_ PSGGV 546_ VADKI 551_ QFSVE 556_ MCFDN 561_ QVSLG 566_ FSPSQ 571_ QLPGA 576_ EVELQ 581_ LQAAP 586_ GSLCA 591_ LRAVD 596_ ESVLL 601_ LRPDR 606_ ELSNR 611_ SVYGM 616_ FPFWY 621_ GHYPY 626_ QVAEY 631_ DQCPV 636_ SGPWD 641_ FPQPL 646_ IDPMP 651_ QGHSS 656_ QRSII 661_ WRPSF 666_ SEGTD 671_ LFSFF 676_ RDVGL 681_ KILSN 686_ AKIKK 691_ PVDCS 696_ HRSPE 701_ YSTAM 706_ GAGGG 711_ HPEAF 716_ ESSTP 721_ LHQAE 726_ DSQVR 731_ QYFPE 736_ TWLWD 741_ LFPIG 746_ NSGKE 751_ AVHVT 756_ VPDAI 761_ TEWKA 766_ MSFCT 771_ SQSRG 776_ FGLSP 781_ TVGLT 786_ AFKPF 791_ FVDLT 796_ LPYSV 801_ VRGES 806_ FRLTA 811_ TIFNY 816_ LKDCI 821_ RVQTD 826_ LAKSH 831_ EYQLE 836_ SWADS 841_ QTSSC 846_ LCADD 851_ AKTHH 856_ WNITA 861_ VKLGH 866_ INFTI 871_ STKIL 876_ DSNEP 881_ CGGQK 886_ GFVPQ 891_ KGRSD 896_ TLIKP 901_ VLVKP 906_ EGVLV 911_ EKTHS 916_ SLLCP 921_ KGKVA 926_ SESVS 931_ LELPV 936_ DIVPD 941_ STKAY 946_ VTVLG 951_ DIMGT 956_ ALQNL 961_ DGLVQ 966_ MPSGC 971_ GEQNM 976_ VLFAP 981_ IIYVL 986_ QYLEK 991_ AGLLT 996_ EEIRS 1001_ RAVGF 1006_ LEIGY 1011_ QKELM 1016_ YKHSN 1021_ GSYSA 1026_ FGERD 1031_ GNGNT 1036_ WLTAF 1041_ VTKCF 1046_ GQAQK 1051_ FIFID 1056_ PKNIQ 1061_ DALKW 1066_ MAGNQ 1071_ LPSGC 1076_ YANVG 1081_ NLLHT 1086_ AMKGG 1091_ VDDEV 1096_ SLTAY 1101_ VTAAL 1106_ LEMGK 1111_ DVDDP 1116_ MVSQG 1121_ LRCLK 1126_ NSATS 1131_ TTNLY 1136_ TQALL 1141_ AYIFS 1146_ LAGEM 1151_ DIRNI 1156_ LLKQL 1161_ DQQAI 1166_ ISGES 1171_ IYWSQ 1176_ KPTPS 1181_ SNASP 1186_ WSEPA 1191_ AVDVE 1196_ LTAYA 1201_ LLAQL 1206_ TKPSL 1211_ TQKEI 1216_ AKATS 1221_ IVAWL 1226_ AKQHN 1231_ AYGGF 1236_ SSTQD 1241_ TVVAL 1246_ QALAK 1251_ YATTA 1256_ YMPSE 1261_ EINLV 1266_ VKSTE 1271_ NFQRT 1276_ FNIQS 1281_ VNRLV 1286_ FQQDT 1291_ LPNVP 1296_ GMYTL 1301_ EASGQ 1306_ GCVYV 1311_ QTVLR 1316_ YNILP 1321_ PTNMK 1326_ TFSLS 1331_ VEIGK 1336_ ARCEQ 1341_ PTSPR 1346_ SLTLT 1351_ IHTSY 1356_ VGSRS 1361_ SSNMA 1366_ IVEVK 1371_ MLSGF 1376_ SPMEG 1381_ TNQLL 1386_ LQQPL 1391_ VKKVE 1396_ FGTDT 1401_ LNIYL 1406_ DELIK 1411_ NTQTY 1416_ TFTIS 1421_ QSVLV 1426_ TNLKP 1431_ ATIKV 1436_ YDYYL 1441_ PDEQA 1446_TIQYS
1: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases