Gene name: RNF212B

Uniprot entry:

A8MTL3

Protein names:

RING finger protein 212B

Protein sequence:

1_MDWFH 6_ CNQCF 11_ RKDGA 16_ HFFVT 21_ SCGHI 26_ FCKKC 31_ VTLEK 36_ CAVCG 41_ TACKH 46_ LALSD 51_ NLKPQ 56_ EKMFF 61_ KSPVE 66_ TALQY 71_ FSHIS 76_ QVWSF 81_ QKKQT 86_ DLLIA 91_ FYKHR 96_ ITKLE 101_ TAMQE 106_ AQQAL 111_ VSQDK 116_ ELSVL 121_ RKENG 126_ ELKKF 131_ LAILK 136_ ESPSR 141_ YQGSR 146_ SITPR 151_ PVGIT 156_ SPSQS 161_ VTPRP 166_ SFQHS 171_ SQVVS 176_ RSSSA 181_ ESIPY 186_ REAGF 191_ GSLGQ 196_ GGRGL 201_ QGRRT 206_ PRDSY 211_ NETPS 216_ PASTH 221_ SLSYR 226_ TSSAS 231_ SGQGI 236_ FSFRP 241_ SPNGH 246_ SGHTR 251_ VLTPN 256_ NFAQR 261_ ESTTT 266_ LESLP 271_ SFQLP 276_ VLQTL 281_ YQQRR 286_ HMGLP 291_SGREA

Protein annotations

Protein functions:

1: Ubiquitin E3 ligase that acts as a crucial factor for crossing-over (CO) formation during meiosis. Essential for normal prophase I progression and for ensuring appropriate CO designation in meiosis. Recruits key components of the cross-over machinery either directly ou indirectly, leading to the activation of the MutL-gamma complex. The function of RNF212B in CO designation is dependent on its catalytic activity