Homeobox protein notochord
1_MPSPR 6_ PRGSP 11_ PPAPS 16_ GSRVR 21_ PPRSG 26_ RSPAP 31_ RSPTG 36_ PNTPR 41_ APGRF 46_ ESPFS 51_ VEAIL 56_ ARPDP 61_ CAPAA 66_ SQPSG 71_ SACVH 76_ PAFWT 81_ AASLC 86_ ATGGL 91_ PWACP 96_ TSWLP 101_ AYLSV 106_ GFYPV 111_ PGPRV 116_ APVCG 121_ LLGFG 126_ VTGLE 131_ LAHCS 136_ GLWAF 141_ PDWAP 146_ TEDLQ 151_ DTERQ 156_ QKRVR 161_ TMFNL 166_ EQLEE 171_ LEKVF 176_ AKQHN 181_ LVGKK 186_ RAQLA 191_ ARLKL 196_ TENQV 201_ RVWFQ 206_ NRRVK 211_ YQKQQ 216_ KLRAA 221_ VTSAE 226_ AASLD 231_ EPSSS 236_ SIASI 241_ QSDDA 246_ESGVD
1: Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity)