BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa)
1_MLKAA 6_ AKRPE 11_ LSGKN 16_ TISNN 21_ SDMAE 26_ VKSMF 31_ REVLP 36_ KQGPL 41_ FVEDI 46_ MTMVL 51_ CKPKL 56_ LPLKS 61_ LTLEK 66_ LEKMH 71_ QAAQN 76_ TIRQQ 81_ EMAEK 86_DQRQI
1: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation