V-set and transmembrane domain-containing protein 5
1_MRPLP 6_ SGRRK 11_ TRGIS 16_ LGLFA 21_ LCLAA 26_ ARCLQ 31_ SQGVS 36_ LYIPQ 41_ ATINA 46_ TVKED 51_ ILLSV 56_ EYSCH 61_ GVPTI 66_ EWTYS 71_ SNWGT 76_ QKIVE 81_ WKPGT 86_ QANIS 91_ QSHKD 96_ RVCTF 101_ DNGSI 106_ QLFSV 111_ GVRDS 116_ GYYVI 121_ TVTER 126_ LGSSQ 131_ FGTIV 136_ LHVSE 141_ ILYED 146_ LHFVA 151_ VILAF 156_ LAAVA 161_ AVLIS 166_ LMWVC 171_ NKCAY 176_ KFQRK 181_ RRHKL 186_ KESTT 191_EEIEL
1: Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain