Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19)
1_MSSSL 6_ RPGPS 11_ RWRRA 16_ ASIVL 21_ AAGWS 26_ RPETA 31_ TPPSR 36_ PPPAE 41_ GFRLL 46_ LLQRS 51_ PHQGF 56_ MPGAH 61_ VFSGG 66_ VLDAA 71_ DRSAD 76_ WLGLF 81_ APHHG 86_ PPRFG 91_ LGPAP 96_ FSRTA 101_ FPSLP 106_ DTDDH 111_ KTDNT 116_ GTLPE 121_ DVAFR 126_ ICAVR 131_ EAFEE 136_ AGVLL 141_ LRPRT 146_ SPPGP 151_ APGPG 156_ LALEP 161_ PPGLA 166_ SWRDR 171_ VRQDP 176_ RHFLR 181_ LCAHL 186_ DCTPD 191_ IWALH 196_ NWSAW 201_ LTPFL 206_ RGTTR 211_ RFDTA 216_ FFLCC 221_ LREPP 226_ PVYPD 231_ LAEVV 236_ GYQWS 241_ SPSEA 246_ TESFL 251_ SKEIW 256_ LPPPQ 261_ FYEVR 266_ RLANF 271_ ASLSD 276_ LHKFC 281_ LGRAL 286_ EGLER 291_ WLPII 296_ LLTAD 301_ GMVHL 306_ LPGDE 311_ LYLED 316_ SDFLE 321_ NLMST 326_ EKKTE 331_ EIMKE 336_ GKQFH 341_ RIVTY 346_ HRHLY 351_ DIHVT 356_ VQPKY 361_ KHVYP 366_KNSVV
1: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)