EF-hand calcium-binding domain-containing protein 9
1_MRLKQ 6_ GSFLW 11_ YLYLD 16_ KIYCL 21_ LSVRN 26_ VKALA 31_ EYFHI 36_ LDVHG 41_ KNTLN 46_ DVLFY 51_ HFLHH 56_ VTDLK 61_ KAQIN 66_ IVFDM 71_ LDWNA 76_ VGEID 81_ FEKFY 86_ MLVCM 91_ LLAHQ 96_ NHLEG 101_ QFMYR 106_ HSRPV 111_ FDLLD 116_ LKGDL 121_ RIGAK 126_ NFEMY 131_ RFLFN 136_ IQKQE 141_ LKDLF 146_ RDFDI 151_ TGDNR 156_ LNYQE 161_ FKLYT 166_ IIYTD 171_ KLQKR 176_ QKTEE 181_ KEKGE 186_ RKRSL 191_YSKCH
1: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel