Eukaryotic translation initiation factor 3 subunit C-like protein
1_MSRFF 6_ TTGSD 11_ SESES 16_ SLSGE 21_ ELVTK 26_ PVGGN 31_ YGKQP 36_ LLLSE 41_ DEEDT 46_ KRVVR 51_ SAKDK 56_ RFEEL 61_ TNLIR 66_ TIRNA 71_ MKIRD 76_ VTKCL 81_ EEFEL 86_ LGKAY 91_ GKAKS 96_ IVDKE 101_ GVPRF 106_ YIRIL 111_ ADLED 116_ YLNEL 121_ WEDKE 126_ GKKKM 131_ NKNNA 136_ KALST 141_ LRQKI 146_ RKYNR 151_ DFESH 156_ ITSYK 161_ QNPEQ 166_ SADED 171_ AEKNE 176_ EDSEG 181_ SSDED 186_ EDEDG 191_ VSAAT 196_ FLKKK 201_ SEAPS 206_ GESRK 211_ FLKKM 216_ DDEDE 221_ DSEDS 226_ EDDED 231_ WDTGS 236_ TSSDS 241_ DSEEE 246_ EGKQT 251_ ALASR 256_ FLKKA 261_ PTTDE 266_ DKKAA 271_ EKKRE 276_ DKAKK 281_ KHDRK 286_ SKRLD 291_ EEEEE 296_ DNEGG 301_ EWERV 306_ RGGVP 311_ LVKEK 316_ PKMFA 321_ KGTEI 326_ THAVV 331_ IKKLN 336_ EILQA 341_ RGKKG 346_ TDRAA 351_ QIELL 356_ QLLVQ 361_ IAAEN 366_ NLGEG 371_ VIVKI 376_ KFNII 381_ ASLYD 386_ YNPNL 391_ ATYMK 396_ PEMWG 401_ KCLDC 406_ INELM 411_ DILFA 416_ NPNIF 421_ VGENI 426_ LEESE 431_ NLHNA 436_ DQPLR 441_ VRGCI 446_ LTLVE 451_ RMDEE 456_ FTKIM 461_ QNTDP 466_ HSQEY 471_ VEHLK 476_ DEAQV 481_ CAIIE 486_ RVQRY 491_ LEEKG 496_ TTEEV 501_ CRIYL 506_ LRILH 511_ TYYKF 516_ DYKAH 521_ QRQLT 526_ PPEGS 531_ SKSEQ 536_ DQAEN 541_ EGEDS 546_ AVLME 551_ RLCKY 556_ IYAKD 561_ RTDRI 566_ RTCAI 571_ LCHIY 576_ HHALH 581_ SRWYQ 586_ ARDLM 591_ LMSHL 596_ QDNIQ 601_ HADPP 606_ VQILY 611_ NRTMV 616_ QLGIC 621_ AFRQG 626_ LTKDA 631_ HNALL 636_ DIQSS 641_ GRAKE 646_ LLGQG 651_ LLLRS 656_ LQERN 661_ QEQEK 666_ VERRR 671_ QVPFH 676_ LHINL 681_ ELLEC 686_ VYLVS 691_ AMLLE 696_ IPYMA 701_ AHESD 706_ ARRRM 711_ ISKQF 716_ HHQLR 721_ VGERQ 726_ PLLGP 731_ PESMR 736_ EHVVA 741_ ASKAM 746_ KMGDW 751_ KTCHS 756_ FIINE 761_ KMNGK 766_ VWDLF 771_ PEADK 776_ VRTML 781_ VRKIQ 786_ EESLR 791_ TYLFT 796_ YSSVY 801_ DSISM 806_ ETLSD 811_ MFELD 816_ LPTVH 821_ SIISK 826_ MIINE 831_ ELMAS 836_ LDQPT 841_ QTVVM 846_ HRTEP 851_ TAQQN 856_ LALQL 861_ AEKLG 866_ SLVEN 871_ NERVF 876_ DHKQG 881_ TYGGY 886_ FRDQK 891_ DGYRK 896_ NEGYM 901_ RRGGY 906_RQQQS
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression