Gene name: HOXB-AS3

Uniprot entry:

C0HLZ6

Protein names:

HOXB-AS3 peptide

Protein sequence:

1_MPVLP 6_ GTQRY 11_ PHQRR 16_ RFQAA 21_ GGGAE 26_ SGKRG 31_ SEEAP 36_ GVAWS 41_ GSESG 46_RDAAT

Protein annotations

Protein functions:

1: Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform (PubMed:28985503). Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a) (PubMed:28985503). Promotes MYC stability through interaction with IGF2BP2 (PubMed:34457052)