Putative WAS protein family homolog 3 (Protein FAM39DP)
1_MTPVR 6_ MQHSL 11_ AGQTY 16_ AVPLI 21_ QPDLR 26_ REEAV 31_ QQMAD 36_ ALQYL 41_ QKVSG 46_ DIFSR 51_ ISQQV 56_ EQSRS 61_ QVQAI 66_ GEKVS 71_ LAQAK 76_ IEKIK 81_ GSKKA 86_ IKVFS 91_ SAKYP 96_ APERL 101_ QEYGS 106_ IFTGA 111_ QDPGL 116_ QRRPR 121_ HRIQS 126_ KHRPL 131_ DERAL 136_ QEKDF 141_ PVCVS 146_ TKPEP 151_ EDDAE 156_ EGLGG 161_ LPSNI 166_ SSVSS 171_ LLLFN 176_ TTENL 181_ GKKYV 186_ FLDPL 191_ AGAVT 196_ KTHVM 201_ LGAET 206_ EEKLF 211_ DAPLS 216_ ISKRE 221_ QLEQQ 226_ VPENY 231_ FYVPD 236_ LGQVP 241_ EIDVP 246_ SYLPD 251_ LPGIT 256_ NDLMY 261_ IADLG 266_ PGIAP 271_ SAPGT 276_ IPELP 281_ TFHTE 286_ VAEPL 291_ KVDLQ 296_ DGVLT 301_ PPPPP 306_ PPPPP 311_ APEVL 316_ ASAPP 321_ LPPST 326_ AAPVG 331_ QGARQ 336_ DDSSS 341_ SASPS 346_ VQGAP 351_ REVVD 356_ PSGGR 361_ ATLLE 366_ SIRQA 371_ GGIGK 376_ AKLRS 381_ MKERK 386_ LEKKQ 391_ QKEQE 396_ QVRAT 401_ SQGGH 406_ LMSDL 411_ FNKLV 416_ MRRKG 421_ ISGKG 426_ PGAGE 431_ GPGGA 436_ FARVS 441_ DSIPP 446_ LPPPQ 451_ QPQAE 456_EDEDD
1: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity)