Gene name: MCRIP1

Uniprot entry:

C9JLW8

Protein names:

Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)

Protein sequence:

1_MTSSP 6_ VSRVV 11_ YNGKR 16_ TSSPR 21_ SPPSS 26_ SEIFT 31_ PAHEE 36_ NVRFI 41_ YEAWQ 46_ GVERD 51_ LRGQV 56_ PGGER 61_ GLVEE 66_ YVEKV 71_ PNPSL 76_ KTFKP 81_ IDLSD 86_ LKRRS 91_TQDAK

Protein annotations

Protein functions:

1: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771)