Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64)
1_MATFV 6_ ELSTK 11_ AKMPI 16_ VGLGT 21_ WRSLL 26_ GKVKE 31_ AVKVA 36_ IDAEY 41_ RHIDC 46_ AYFYE 51_ NQHEV 56_ GEAIQ 61_ EKIQE 66_ KAVMR 71_ EDLFI 76_ VSKVW 81_ PTFFE 86_ RPLVR 91_ KAFEK 96_ TLKDL 101_ KLSYL 106_ DVYLI 111_ HWPQG 116_ FKTGD 121_ DFFPK 126_ DDKGN 131_ MISGK 136_ GTFLD 141_ AWEAM 146_ EELVD 151_ EGLVK 156_ ALGVS 161_ NFNHF 166_ QIERL 171_ LNKPG 176_ LKYKP 181_ VTNQV 186_ ECHPY 191_ LTQEK 196_ LIQYC 201_ HSKGI 206_ TVTAY 211_ SPLGS 216_ PDRPW 221_ AKPED 226_ PSLLE 231_ DPKIK 236_ EIAAK 241_ HKKTT 246_ AQVLI 251_ RFHIQ 256_ RNVTV 261_ IPKSM 266_ TPAHI 271_ VENIQ 276_ VFDFK 281_ LSDEE 286_ MATIL 291_ SFNRN 296_ WRAFD 301_ FKEFS 306_ HLEDF 311_PFDAE
1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439)
2: No oxidoreductase activity observed with the tested substrates