Gene name: C11orf94

Uniprot entry:

C9JXX5

Protein names:

Uncharacterized protein C11orf94

Protein sequence:

1_MVLAM 6_ LGALH 11_ PRAGL 16_ SLFLH 21_ LILAV 26_ ALLRS 31_ QPLRS 36_ QRSVP 41_ EAFSA 46_ PLELS 51_ QPLSG 56_ LVDDY 61_ GILPK 66_ HPRPR 71_ GPRPL 76_ LSRAQ 81_ QRKRD 86_ GPDLA 91_EYYYD

Protein annotations

Protein functions:

1: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP