Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)
1_MQACG 6_ GGAAG 11_ RRAFD 16_ SICPN 21_ RMLAL 26_ PGRAL 31_ LCKPG 36_ KPERK 41_ FAPPR 46_ KFFPG 51_ CTGGS 56_ PVSVY 61_ EDPPD 66_ AEPTA 71_ LPALT 76_ TIDLQ 81_ DLADC 86_ SSLLG 91_ SDAPP 96_ GGDLA 101_ ASQNH 106_ SHQTE 111_ ADFNL 116_ QDFRD 121_ TVDDL 126_ ISDSS 131_ SMMSP 136_ TLASG 141_ DFPFS 146_ PCDIS 151_ PFGPC 156_ LSPPL 161_ DPRAL 166_ QSPPL 171_ RPPDV 176_ PPPEQ 181_ YWKEV 186_ ADQNQ 191_ RALGD 196_ ALVEN 201_ NQLHV 206_ TLTQK 211_ QEEIA 216_ SLKER 221_ NVQLK 226_ ELASR 231_ TRHLA 236_ SVLDK 241_ LMITQ 246_ SRDCG 251_ AAAEP 256_ FLLKA 261_ KAKRS 266_ LEELV 271_ SAAGQ 276_ DCAEV 281_ DAILR 286_ EISER 291_ CDEAL 296_ QSRDP 301_ KRPRL 306_ LPEPA 311_ NTDTR 316_ PGNLH 321_ GAFRG 326_ LRTDC 331_ SRSAL 336_ NLSHS 341_ ELEEG 346_ GSFST 351_ RIRSH 356_ STIRT 361_ LAFPQ 366_ GNAFT 371_ IRTAN 376_GGYKF
1: Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211)