Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)
1_MSDLE 6_ AKPST 11_ EHLGD 16_ KIKDE 21_ DIKLR 26_ VIGQD 31_ SSEIH 36_ FKVKM 41_ TTPLK 46_ KLKKS 51_ YCQRQ 56_ GVPVN 61_ SLRFL 66_ FEGQR 71_ IADNH 76_ TPEEL 81_ GMEEE 86_ DVIEV 91_ YQEQI 96_GGHST
1: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs