Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)
1_MIPLL 6_ LAALL 11_ CVPAG 16_ ALTCY 21_ GDSGQ 26_ PVDWF 31_ VVYKL 36_ PALRG 41_ SGEAA 46_ QRGLQ 51_ YKYLD 56_ ESSGG 61_ WRDGR 66_ ALINS 71_ PEGAV 76_ GRSLQ 81_ PLYRS 86_ NTSQL 91_ AFLLY 96_ NDQPP 101_ QPSKA 106_ QDSSM 111_ RGHTK 116_ GVLLL 121_ DHDGG 126_ FWLVH 131_ SVPNF 136_ PPPAS 141_ SAAYS 146_ WPHSA 151_ CTYGQ 156_ TLLCV 161_ SFPFA 166_ QFSKM 171_ GKQLT 176_ YTYPW 181_ VYNYQ 186_ LEGIF 191_ AQEFP 196_ DLENV 201_ VKGHH 206_ VSQEP 211_ WNSSI 216_ TLTSQ 221_ AGAVF 226_ QSFAK 231_ FSKFG 236_ DDLYS 241_ GWLAA 246_ ALGTN 251_ LQVQF 256_ WHKTV 261_ GILPS 266_ NCSDI 271_ WQVLN 276_ VNQIA 281_ FPGPA 286_ GPSFN 291_ STEDH 296_ SKWCV 301_ SPKGP 306_ WTCVG 311_ DMNRN 316_ QGEEQ 321_ RGGGT 326_ LCAQL 331_ PALWK 336_ AFQPL 341_ VKNYQ 346_ PCNGM 351_ARKPS
1: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162)