Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK)
1_MLLWP 6_ LRGWA 11_ ARALR 16_ CFGPG 21_ SRGSP 26_ ASGPG 31_ PRRVQ 36_ RRAWP 41_ PDKEQ 46_ EKEKK 51_ SVICV 56_ EGNIA 61_ SGKTT 66_ CLEFF 71_ SNATD 76_ VEVLT 81_ EPVSK 86_ WRNVR 91_ GHNPL 96_ GLMYH 101_ DASRW 106_ GLTLQ 111_ TYVQL 116_ TMLDR 121_ HTRPQ 126_ VSSVR 131_ LMERS 136_ IHSAR 141_ YIFVE 146_ NLYRS 151_ GKMPE 156_ VDYVV 161_ LSEWF 166_ DWILR 171_ NMDVS 176_ VDLIV 181_ YLRTN 186_ PETCY 191_ QRLKK 196_ RCREE 201_ EKVIP 206_ LEYLE 211_ AIHHL 216_ HEEWL 221_ IKGSL 226_ FPMAA 231_ PVLVI 236_ EADHH 241_ MERML 246_ ELFEQ 251_ NRDRI 256_LTPEN
1: Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:11687801, PubMed:9989599). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599)