Gene name: FZD9

Uniprot entry:

O00144

Protein names:

Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349)

Protein sequence:

1_MAVAP 6_ LRGAL 11_ LLWQL 16_ LAAGG 21_ AALEI 26_ GRFDP 31_ ERGRG 36_ AAPCQ 41_ AVEIP 46_ MCRGI 51_ GYNLT 56_ RMPNL 61_ LGHTS 66_ QGEAA 71_ AELAE 76_ FAPLV 81_ QYGCH 86_ SHLRF 91_ FLCSL 96_ YAPMC 101_ TDQVS 106_ TPIPA 111_ CRPMC 116_ EQARL 121_ RCAPI 126_ MEQFN 131_ FGWPD 136_ SLDCA 141_ RLPTR 146_ NDPHA 151_ LCMEA 156_ PENAT 161_ AGPAE 166_ PHKGL 171_ GMLPV 176_ APRPA 181_ RPPGD 186_ LGPGA 191_ GGSGT 196_ CENPE 201_ KFQYV 206_ EKSRS 211_ CAPRC 216_ GPGVE 221_ VFWSR 226_ RDKDF 231_ ALVWM 236_ AVWSA 241_ LCFFS 246_ TAFTV 251_ LTFLL 256_ EPHRF 261_ QYPER 266_ PIIFL 271_ SMCYN 276_ VYSLA 281_ FLIRA 286_ VAGAQ 291_ SVACD 296_ QEAGA 301_ LYVIQ 306_ EGLEN 311_ TGCTL 316_ VFLLL 321_ YYFGM 326_ ASSLW 331_ WVVLT 336_ LTWFL 341_ AAGKK 346_ WGHEA 351_ IEAHG 356_ SYFHM 361_ AAWGL 366_ PALKT 371_ IVILT 376_ LRKVA 381_ GDELT 386_ GLCYV 391_ ASTDA 396_ AALTG 401_ FVLVP 406_ LSGYL 411_ VLGSS 416_ FLLTG 421_ FVALF 426_ HIRKI 431_ MKTGG 436_ TNTEK 441_ LEKLM 446_ VKIGV 451_ FSILY 456_ TVPAT 461_ CVIVC 466_ YVYER 471_ LNMDF 476_ WRLRA 481_ TEQPC 486_ AAAAG 491_ PGGRR 496_ DCSLP 501_ GGSVP 506_ TVAVF 511_ MLKIF 516_ MSLVV 521_ GITSG 526_ VWVWS 531_ SKTFQ 536_ TWQSL 541_ CYRKI 546_ AAGRA 551_ RAKAC 556_ RAPGS 561_ YGRGT 566_ HCHYK 571_ APTVV 576_ LHMTK 581_ TDPSL 586_ENPTH

Protein annotations

Protein functions:

1: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity)