ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)
1_MAEQD 6_ VENDL 11_ LDYDE 16_ EEEPQ 21_ APQES 26_ TPAPP 31_ KKDIK 36_ GSYVS 41_ IHSSG 46_ FRDFL 51_ LKPEL 56_ LRAIV 61_ DCGFE 66_ HPSEV 71_ QHECI 76_ PQAIL 81_ GMDVL 86_ CQAKS 91_ GMGKT 96_ AVFVL 101_ ATLQQ 106_ IEPVN 111_ GQVTV 116_ LVMCH 121_ TRELA 126_ FQISK 131_ EYERF 136_ SKYMP 141_ SVKVS 146_ VFFGG 151_ LSIKK 156_ DEEVL 161_ KKNCP 166_ HVVVG 171_ TPGRI 176_ LALVR 181_ NRSFS 186_ LKNVK 191_ HFVLD 196_ ECDKM 201_ LEQLD 206_ MRRDV 211_ QEIFR 216_ LTPHE 221_ KQCMM 226_ FSATL 231_ SKDIR 236_ PVCRK 241_ FMQDP 246_ MEVFV 251_ DDETK 256_ LTLHG 261_ LQQYY 266_ VKLKD 271_ SEKNR 276_ KLFDL 281_ LDVLE 286_ FNQVI 291_ IFVKS 296_ VQRCM 301_ ALAQL 306_ LVEQN 311_ FPAIA 316_ IHRGM 321_ AQEER 326_ LSRYQ 331_ QFKDF 336_ QRRIL 341_ VATNL 346_ FGRGM 351_ DIERV 356_ NIVFN 361_ YDMPE 366_ DSDTY 371_ LHRVA 376_ RAGRF 381_ GTKGL 386_ AITFV 391_ SDEND 396_ AKILN 401_ DVQDR 406_ FEVNV 411_ AELPE 416_ EIDIS 421_TYIEQ
1: Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067)