Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
1_MALQV 6_ ELVPT 11_ GEIIR 16_ VVHPH 21_ RPCKL 26_ ALGSD 31_ GVRVT 36_ MESAL 41_ TARDR 46_ VGVQD 51_ FVLLE 56_ NFTSE 61_ AAFIE 66_ NLRRR 71_ FRENL 76_ IYTYI 81_ GPVLV 86_ SVNPY 91_ RDLQI 96_ YSRQH 101_ MERYR 106_ GVSFY 111_ EVPPH 116_ LFAVA 121_ DTVYR 126_ ALRTE 131_ RRDQA 136_ VMISG 141_ ESGAG 146_ KTEAT 151_ KRLLQ 156_ FYAET 161_ CPAPE 166_ RGGAV 171_ RDRLL 176_ QSNPV 181_ LEAFG 186_ NAKTL 191_ RNDNS 196_ SRFGK 201_ YMDVQ 206_ FDFKG 211_ APVGG 216_ HILSY 221_ LLEKS 226_ RVVHQ 231_ NHGER 236_ NFHIF 241_ YQLLE 246_ GGEEE 251_ TLRRL 256_ GLERN 261_ PQSYL 266_ YLVKG 271_ QCAKV 276_ SSIND 281_ KSDWK 286_ VVRKA 291_ LTVID 296_ FTEDE 301_ VEDLL 306_ SIVAS 311_ VLHLG 316_ NIHFA 321_ ANEES 326_ NAQVT 331_ TENQL 336_ KYLTR 341_ LLSVE 346_ GSTLR 351_ EALTH 356_ RKIIA 361_ KGEEL 366_ LSPLN 371_ LEQAA 376_ YARDA 381_ LAKAV 386_ YSRTF 391_ TWLVG 396_ KINRS 401_ LASKD 406_ VESPS 411_ WRSTT 416_ VLGLL 421_ DIYGF 426_ EVFQH 431_ NSFEQ 436_ FCINY 441_ CNEKL 446_ QQLFI 451_ ELTLK 456_ SEQEE 461_ YEAEG 466_ IAWEP 471_ VQYFN 476_ NKIIC 481_ DLVEE 486_ KFKGI 491_ ISILD 496_ EECLR 501_ PGEAT 506_ DLTFL 511_ EKLED 516_ TVKHH 521_ PHFLT 526_ HKLAD 531_ QRTRK 536_ SLGRG 541_ EFRLL 546_ HYAGE 551_ VTYSV 556_ TGFLD 561_ KNNDL 566_ LFRNL 571_ KETMC 576_ SSKNP 581_ IMSQC 586_ FDRSE 591_ LSDKK 596_ RPETV 601_ ATQFK 606_ MSLLQ 611_ LVEIL 616_ QSKEP 621_ AYVRC 626_ IKPND 631_ AKQPG 636_ RFDEV 641_ LIRHQ 646_ VKYLG 651_ LLENL 656_ RVRRA 661_ GFAYR 666_ RKYEA 671_ FLQRY 676_ KSLCP 681_ ETWPT 686_ WAGRP 691_ QDGVA 696_ VLVRH 701_ LGYKP 706_ EEYKM 711_ GRTKI 716_ FIRFP 721_ KTLFA 726_ TEDAL 731_ EVRRQ 736_ SLATK 741_ IQAAW 746_ RGFHW 751_ RQKFL 756_ RVKRS 761_ AICIQ 766_ SWWRG 771_ TLGRR 776_ KAAKR 781_ KWAAQ 786_ TIRRL 791_ IRGFV 796_ LRHAP 801_ RCPEN 806_ AFFLD 811_ HVRTS 816_ FLLNL 821_ RRQLP 826_ QNVLD 831_ TSWPT 836_ PPPAL 841_ REASE 846_ LLREL 851_ CIKNM 856_ VWKYC 861_ RSISP 866_ EWKQQ 871_ LQQKA 876_ VASEI 881_ FKGKK 886_ DNYPQ 891_ SVPRL 896_ FISTR 901_ LGTDE 906_ ISPRV 911_ LQALG 916_ SEPIQ 921_ YAVPV 926_ VKYDR 931_ KGYKP 936_ RSRQL 941_ LLTPN 946_ AVVIV 951_ EDAKV 956_ KQRID 961_ YANLT 966_ GISVS 971_ SLSDS 976_ LFVLH 981_ VQRAD 986_ NKQKG 991_ DVVLQ 996_ SDHVI 1001_ ETLTK 1006_ TALSA 1011_ NRVNS 1016_ ININQ 1021_ GSITF 1026_ AGGPG 1031_ RDGTI 1036_ DFTPG 1041_ SELLI 1046_ TKAKN 1051_ GHLAV 1056_VAPRL
1: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes
2: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation