HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)
1_MSLFD 6_ LFRGF 11_ FGFPG 16_ PRSHR 21_ DPFFG 26_ GMTRD 31_ EDDDE 36_ EEEEE 41_ GGSWG 46_ RGNPR 51_ FHSPQ 56_ HPPEE 61_ FGFGF 66_ SFSPG 71_ GGIRF 76_ HDNFG 81_ FDDLV 86_ RDFNS 91_ IFSDM 96_ GAWTL 101_ PSHPP 106_ ELPGP 111_ ESETP 116_ GERLR 121_ EGQTL 126_ RDSML 131_ KYPDS 136_ HQPRI 141_ FGGVL 146_ ESDAR 151_ SESPQ 156_ PAPDW 161_ GSQRP 166_ FHRFD 171_ DVWPM 176_ DPHPR 181_ TREDN 186_ DLDSQ 191_ VSQEG 196_ LGPVL 201_ QPQPK 206_ SYFKS 211_ ISVTK 216_ ITKPD 221_ GIVEE 226_ RRTVV 231_ DSEGR 236_ TETTV 241_ TRHEA 246_ DSSPR 251_ GDPES 256_ PRPPA 261_ LDDAF 266_ SILDL 271_FLGRW
1: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools