Eyes absent homolog 2 (EC 3.1.3.48)
1_MVELV 6_ ISPSL 11_ TVNSD 16_ CLDKL 21_ KFNRA 26_ DAAVW 31_ TLSDR 36_ QGITK 41_ SAPLR 46_ VSQLF 51_ SRSCP 56_ RVLPR 61_ QPSTA 66_ MAAYG 71_ QTQYS 76_ AGIQQ 81_ ATPYT 86_ AYPPP 91_ AQAYG 96_ IPSYS 101_ IKTED 106_ SLNHS 111_ PGQSG 116_ FLSYG 121_ SSFST 126_ SPTGQ 131_ SPYTY 136_ QMHGT 141_ TGFYQ 146_ GGNGL 151_ GNAAG 156_ FGSVH 161_ QDYPS 166_ YPGFP 171_ QSQYP 176_ QYYGS 181_ SYNPP 186_ YVPAS 191_ SICPS 196_ PLSTS 201_ TYVLQ 206_ EASHN 211_ VPNQS 216_ SESLA 221_ GEYNT 226_ HNGPS 231_ TPAKE 236_ GDTDR 241_ PHRAS 246_ DGKLR 251_ GRSKR 256_ SSDPS 261_ PAGDN 266_ EIERV 271_ FVWDL 276_ DETII 281_ IFHSL 286_ LTGTF 291_ ASRYG 296_ KDTTT 301_ SVRIG 306_ LMMEE 311_ MIFNL 316_ ADTHL 321_ FFNDL 326_ EDCDQ 331_ IHVDD 336_ VSSDD 341_ NGQDL 346_ STYNF 351_ SADGF 356_ HSSAP 361_ GANLC 366_ LGSGV 371_ HGGVD 376_ WMRKL 381_ AFRYR 386_ RVKEM 391_ YNTYK 396_ NNVGG 401_ LIGTP 406_ KRETW 411_ LQLRA 416_ ELEAL 421_ TDLWL 426_ THSLK 431_ ALNLI 436_ NSRPN 441_ CVNVL 446_ VTTTQ 451_ LIPAL 456_ AKVLL 461_ YGLGS 466_ VFPIE 471_ NIYSA 476_ TKTGK 481_ ESCFE 486_ RIMQR 491_ FGRKA 496_ VYVVI 501_ GDGVE 506_ EEQGA 511_ KKHNM 516_ PFWRI 521_ SCHAD 526_ LEALR 531_HALEL
1: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905)