Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1)
1_MASLG 6_ HILVF 11_ CVGLL 16_ TMAKA 21_ ESPKE 26_ HDPFT 31_ YDYQS 36_ LQIGG 41_ LVIAG 46_ ILFIL 51_ GILIV 56_ LSRRC 61_ RCKFN 66_ QQQRT 71_ GEPDE 76_ EEGTF 81_ RSSIR 86_RLSTR
1: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone