Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
1_MRLLT 6_ LLGLL 11_ CGSVA 16_ TPLGP 21_ KWPEP 26_ VFGRL 31_ ASPGF 36_ PGEYA 41_ NDQER 46_ RWTLT 51_ APPGY 56_ RLRLY 61_ FTHFD 66_ LELSH 71_ LCEYD 76_ FVKLS 81_ SGAKV 86_ LATLC 91_ GQEST 96_ DTERA 101_ PGKDT 106_ FYSLG 111_ SSLDI 116_ TFRSD 121_ YSNEK 126_ PFTGF 131_ EAFYA 136_ AEDID 141_ ECQVA 146_ PGEAP 151_ TCDHH 156_ CHNHL 161_ GGFYC 166_ SCRAG 171_ YVLHR 176_ NKRTC 181_ SALCS 186_ GQVFT 191_ QRSGE 196_ LSSPE 201_ YPRPY 206_ PKLSS 211_ CTYSI 216_ SLEEG 221_ FSVIL 226_ DFVES 231_ FDVET 236_ HPETL 241_ CPYDF 246_ LKIQT 251_ DREEH 256_ GPFCG 261_ KTLPH 266_ RIETK 271_ SNTVT 276_ ITFVT 281_ DESGD 286_ HTGWK 291_ IHYTS 296_ TAQPC 301_ PYPMA 306_ PPNGH 311_ VSPVQ 316_ AKYIL 321_ KDSFS 326_ IFCET 331_ GYELL 336_ QGHLP 341_ LKSFT 346_ AVCQK 351_ DGSWD 356_ RPMPA 361_ CSIVD 366_ CGPPD 371_ DLPSG 376_ RVEYI 381_ TGPGV 386_ TTYKA 391_ VIQYS 396_ CEETF 401_ YTMKV 406_ NDGKY 411_ VCEAD 416_ GFWTS 421_ SKGEK 426_ SLPVC 431_ EPVCG 436_ LSART 441_ TGGRI 446_ YGGQK 451_ AKPGD 456_ FPWQV 461_ LILGG 466_ TTAAG 471_ ALLYD 476_ NWVLT 481_ AAHAV 486_ YEQKH 491_ DASAL 496_ DIRMG 501_ TLKRL 506_ SPHYT 511_ QAWSE 516_ AVFIH 521_ EGYTH 526_ DAGFD 531_ NDIAL 536_ IKLNN 541_ KVVIN 546_ SNITP 551_ ICLPR 556_ KEAES 561_ FMRTD 566_ DIGTA 571_ SGWGL 576_ TQRGF 581_ LARNL 586_ MYVDI 591_ PIVDH 596_ QKCTA 601_ AYEKP 606_ PYPRG 611_ SVTAN 616_ MLCAG 621_ LESGG 626_ KDSCR 631_ GDSGG 636_ ALVFL 641_ DSETE 646_ RWFVG 651_ GIVSW 656_ GSMNC 661_ GEAGQ 666_ YGVYT 671_ KVINY 676_ IPWIE 681_NIISD
1: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase