AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)
1_MISQF 6_ FILSS 11_ KGDPL 16_ IYKDF 21_ RGDSG 26_ GRDVA 31_ ELFYR 36_ KLTGL 41_ PGDES 46_ PVVMH 51_ HHGRH 56_ FIHIR 61_ HSGLY 66_ LVVTT 71_ SENVS 76_ PFSLL 81_ ELLSR 86_ LATLL 91_ GDYCG 96_ SLGEG 101_ TISRN 106_ VALVY 111_ ELLDE 116_ VLDYG 121_ YVQTT 126_ STEML 131_ RNFIQ 136_ TEAVV 141_ SKPFS 146_ LFDLS 151_ SVGLF 156_ GAETQ 161_ QSKVA 166_ PSSAA 171_ SRPVL 176_ SSRSD 181_ QSQKN 186_ EVFLD 191_ VVERL 196_ SVLIA 201_ SNGSL 206_ LKVDV 211_ QGEIR 216_ LKSFL 221_ PSGSE 226_ MRIGL 231_ TEEFC 236_ VGKSE 241_ LRGYG 246_ PGIRV 251_ DEVSF 256_ HSSVN 261_ LDEFE 266_ SHRIL 271_ RLQPP 276_ QGELT 281_ VMRYQ 286_ LSDDL 291_ PSPLP 296_ FRLFP 301_ SVQWD 306_ RGSGR 311_ LQVYL 316_ KLRCD 321_ LLSKS 326_ QALNV 331_ RLHLP 336_ LPRGV 341_ VSLSQ 346_ ELSSP 351_ EQKAE 356_ LAEGA 361_ LRWDL 366_ PRVQG 371_ GSQLS 376_ GLFQM 381_ DVPGP 386_ PGPPS 391_ HGLST 396_ SASPL 401_ GLGPA 406_ SLSFE 411_ LPRHT 416_ CSGLQ 421_ VRFLR 426_ LAFRP 431_ CGNAN 436_ PHKWV 441_ RHLSH 446_SDAYV
1: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028, PubMed:11139587, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:20230749, PubMed:26544806). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity)