Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1)
1_MDGPA 6_ EPQIP 11_ GLWDT 16_ YEDDI 21_ SEISQ 26_ KLPGE 31_ YFRYK 36_ GVPFP 41_ VGLYS 46_ LESIS 51_ LAENT 56_ QDVRD 61_ DDIFI 66_ ITYPK 71_ SGTTW 76_ MIEII 81_ CLILK 86_ EGDPS 91_ WIRSV 96_ PIWER 101_ APWCE 106_ TIVGA 111_ FSLPD 116_ QYSPR 121_ LMSSH 126_ LPIQI 131_ FTKAF 136_ FSSKA 141_ KVIYM 146_ GRNPR 151_ DVVVS 156_ LYHYS 161_ KIAGQ 166_ LKDPG 171_ TPDQF 176_ LRDFL 181_ KGEVQ 186_ FGSWF 191_ DHIKG 196_ WLRMK 201_ GKDNF 206_ LFITY 211_ EELQQ 216_ DLQGS 221_ VERIC 226_ GFLGR 231_ PLGKE 236_ ALGSV 241_ VAHST 246_ FSAMK 251_ ANTMS 256_ NYTLL 261_ PPSLL 266_ DHRRG 271_ AFLRK 276_ GVCGD 281_ WKNHF 286_ TVAQS 291_ EAFDR 296_ AYRKQ 301_ MRGMP 306_ TFPWD 311_ EDPEE 316_ DGSPD 321_ PEPSP 326_ EPEPK 331_ PSLEP 336_ NTSLE 341_ REPRP 346_ NSSPS 351_ PSPGQ 356_ASETP
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648)
2: Sulfonates pregnenolone but not cholesterol