Toll-like receptor 4 (hToll) (CD antigen CD284)
1_MMSAS 6_ RLAGT 11_ LIPAM 16_ AFLSC 21_ VRPES 26_ WEPCV 31_ EVVPN 36_ ITYQC 41_ MELNF 46_ YKIPD 51_ NLPFS 56_ TKNLD 61_ LSFNP 66_ LRHLG 71_ SYSFF 76_ SFPEL 81_ QVLDL 86_ SRCEI 91_ QTIED 96_ GAYQS 101_ LSHLS 106_ TLILT 111_ GNPIQ 116_ SLALG 121_ AFSGL 126_ SSLQK 131_ LVAVE 136_ TNLAS 141_ LENFP 146_ IGHLK 151_ TLKEL 156_ NVAHN 161_ LIQSF 166_ KLPEY 171_ FSNLT 176_ NLEHL 181_ DLSSN 186_ KIQSI 191_ YCTDL 196_ RVLHQ 201_ MPLLN 206_ LSLDL 211_ SLNPM 216_ NFIQP 221_ GAFKE 226_ IRLHK 231_ LTLRN 236_ NFDSL 241_ NVMKT 246_ CIQGL 251_ AGLEV 256_ HRLVL 261_ GEFRN 266_ EGNLE 271_ KFDKS 276_ ALEGL 281_ CNLTI 286_ EEFRL 291_ AYLDY 296_ YLDDI 301_ IDLFN 306_ CLTNV 311_ SSFSL 316_ VSVTI 321_ ERVKD 326_ FSYNF 331_ GWQHL 336_ ELVNC 341_ KFGQF 346_ PTLKL 351_ KSLKR 356_ LTFTS 361_ NKGGN 366_ AFSEV 371_ DLPSL 376_ EFLDL 381_ SRNGL 386_ SFKGC 391_ CSQSD 396_ FGTTS 401_ LKYLD 406_ LSFNG 411_ VITMS 416_ SNFLG 421_ LEQLE 426_ HLDFQ 431_ HSNLK 436_ QMSEF 441_ SVFLS 446_ LRNLI 451_ YLDIS 456_ HTHTR 461_ VAFNG 466_ IFNGL 471_ SSLEV 476_ LKMAG 481_ NSFQE 486_ NFLPD 491_ IFTEL 496_ RNLTF 501_ LDLSQ 506_ CQLEQ 511_ LSPTA 516_ FNSLS 521_ SLQVL 526_ NMSHN 531_ NFFSL 536_ DTFPY 541_ KCLNS 546_ LQVLD 551_ YSLNH 556_ IMTSK 561_ KQELQ 566_ HFPSS 571_ LAFLN 576_ LTQND 581_ FACTC 586_ EHQSF 591_ LQWIK 596_ DQRQL 601_ LVEVE 606_ RMECA 611_ TPSDK 616_ QGMPV 621_ LSLNI 626_ TCQMN 631_ KTIIG 636_ VSVLS 641_ VLVVS 646_ VVAVL 651_ VYKFY 656_ FHLML 661_ LAGCI 666_ KYGRG 671_ ENIYD 676_ AFVIY 681_ SSQDE 686_ DWVRN 691_ ELVKN 696_ LEEGV 701_ PPFQL 706_ CLHYR 711_ DFIPG 716_ VAIAA 721_ NIIHE 726_ GFHKS 731_ RKVIV 736_ VVSQH 741_ FIQSR 746_ WCIFE 751_ YEIAQ 756_ TWQFL 761_ SSRAG 766_ IIFIV 771_ LQKVE 776_ KTLLR 781_ QQVEL 786_ YRLLS 791_ RNTYL 796_ EWEDS 801_ VLGRH 806_ IFWRR 811_ LRKAL 816_ LDGKS 821_ WNPEG 826_ TVGTG 831_CNWQE
1: Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634, PubMed:15809303, PubMed:16622205, PubMed:17292937, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:29038465, PubMed:17803912). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+) (PubMed:20711192). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:10835634, PubMed:21393102, PubMed:27022195, PubMed:36945827, PubMed:9237759). Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production (PubMed:14517278). In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade (PubMed:32894580). In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 (PubMed:23880187). Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway (PubMed:23880187). In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner (PubMed:15265881, PubMed:23880187). Required for the migration-promoting effects of ZG16B/PAUF on pancreatic cancer cells