Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
1_MMLSL 6_ NNLQN 11_ IIYNP 16_ VIPFV 21_ GTIPD 26_ QLDPG 31_ TLIVI 36_ RGHVP 41_ SDADR 46_ FQVDL 51_ QNGSS 56_ MKPRA 61_ DVAFH 66_ FNPRF 71_ KRAGC 76_ IVCNT 81_ LINEK 86_ WGREE 91_ ITYDT 96_ PFKRE 101_ KSFEI 106_ VIMVL 111_ KDKFQ 116_ VAVNG 121_ KHTLL 126_ YGHRI 131_ GPEKI 136_ DTLGI 141_ YGKVN 146_ IHSIG 151_ FSFSS 156_ DLQST 161_ QASSL 166_ ELTEI 171_ SRENV 176_ PKSGT 181_ PQLRL 186_ PFAAR 191_ LNTPM 196_ GPGRT 201_ VVVKG 206_ EVNAN 211_ AKSFN 216_ VDLLA 221_ GKSKD 226_ IALHL 231_ NPRLN 236_ IKAFV 241_ RNSFL 246_ QESWG 251_ EEERN 256_ ITSFP 261_ FSPGM 266_ YFEMI 271_ IYCDV 276_ REFKV 281_ AVNGV 286_ HSLEY 291_ KHRFK 296_ ELSSI 301_ DTLEI 306_ NGDIH 311_LLEVR
1: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902)