Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
1_MAPPP 6_ ARVHL 11_ GAFLA 16_ VTPNP 21_ GSAAS 26_ GTEAA 31_ AATPS 36_ KVWGS 41_ SAGRI 46_ EPRGG 51_ GRGAL 56_ PTSMG 61_ QHGPS 66_ ARARA 71_ GRAPG 76_ PRPAR 81_ EASPR 86_ LRVHK 91_ TFKFV 96_ VVGVL 101_ LQVVP 106_ SSAAT 111_ IKLHD 116_ QSIGT 121_ QQWEH 126_ SPLGE 131_ LCPPG 136_ SHRSE 141_ HPGAC 146_ NRCTE 151_ GVGYT 156_ NASNN 161_ LFACL 166_ PCTAC 171_ KSDEE 176_ ERSPC 181_ TTTRN 186_ TACQC 191_ KPGTF 196_ RNDNS 201_ AEMCR 206_ KCSRG 211_ CPRGM 216_ VKVKD 221_ CTPWS 226_ DIECV 231_ HKESG 236_ NGHNI 241_ WVILV 246_ VTLVV 251_ PLLLV 256_ AVLIV 261_ CCCIG 266_ SGCGG 271_ DPKCM 276_ DRVCF 281_ WRLGL 286_ LRGPG 291_ AEDNA 296_ HNEIL 301_ SNADS 306_ LSTFV 311_ SEQQM 316_ ESQEP 321_ ADLTG 326_ VTVQS 331_ PGEAQ 336_ CLLGP 341_ AEAEG 346_ SQRRR 351_ LLVPA 356_ NGADP 361_ TETLM 366_ LFFDK 371_ FANIV 376_ PFDSW 381_ DQLMR 386_ QLDLT 391_ KNEID 396_ VVRAG 401_ TAGPG 406_ DALYA 411_ MLMKW 416_ VNKTG 421_ RNASI 426_ HTLLD 431_ ALERM 436_ EERHA 441_ REKIQ 446_ DLLVD 451_ SGKFI 456_ YLEDG 461_TGSAV
1: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227)