26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
1_MAAAA 6_ VVEFQ 11_ RAQSL 16_ LSTDR 21_ EASID 26_ ILHSI 31_ VKRDI 36_ QENDE 41_ EAVQV 46_ KEQSI 51_ LELGS 56_ LLAKT 61_ GQAAE 66_ LGGLL 71_ KYVRP 76_ FLNSI 81_ SKAKA 86_ ARLVR 91_ SLLDL 96_ FLDME 101_ AATGQ 106_ EVELC 111_ LECIE 116_ WAKSE 121_ KRTFL 126_ RQALE 131_ ARLVS 136_ LYFDT 141_ KRYQE 146_ ALHLG 151_ SQLLR 156_ ELKKM 161_ DDKAL 166_ LVEVQ 171_ LLESK 176_ TYHAL 181_ SNLPK 186_ ARAAL 191_ TSART 196_ TANAI 201_ YCPPK 206_ LQATL 211_ DMQSG 216_ IIHAA 221_ EEKDW 226_ KTAYS 231_ YFYEA 236_ FEGYD 241_ SIDSP 246_ KAITS 251_ LKYML 256_ LCKIM 261_ LNTPE 266_ DVQAL 271_ VSGKL 276_ ALRYA 281_ GRQTE 286_ ALKCV 291_ AQASK 296_ NRSLA 301_ DFEKA 306_ LTDYR 311_ AELRD 316_ DPIIS 321_ THLAK 326_ LYDNL 331_ LEQNL 336_ IRVIE 341_ PFSRV 346_ QIEHI 351_ SSLIK 356_ LSKAD 361_ VERKL 366_ SQMIL 371_ DKKFH 376_ GILDQ 381_ GEGVL 386_ IIFDE 391_ PPVDK 396_ TYEAA 401_ LETIQ 406_ NMSKV 411_ VDSLY 416_NKAKK
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity