Agouti-related protein
1_MLTAA 6_ VLSCA 11_ LLLAL 16_ PATRG 21_ AQMGL 26_ APMEG 31_ IRRPD 36_ QALLP 41_ ELPGL 46_ GLRAP 51_ LKKTT 56_ AEQAE 61_ EDLLQ 66_ EAQAL 71_ AEVLD 76_ LQDRE 81_ PRSSR 86_ RCVRL 91_ HESCL 96_ GQQVP 101_ CCDPC 106_ ATCYC 111_ RFFNA 116_ FCYCR 121_ KLGTA 126_MNPCS
1: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner